Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders, immuno-inflammation, and endothelial dysfunction

Cell Communication and Signaling

Review

LiShuo Dong¹  Linhua Zhao²  Xiaolin Tong²  Keyu Chen³  Chongxiang Xue³  Tingting Bao³  Zezheng Gao⁴  Xiuyang Li⁴ 

[1] Changchun University of Traditional Chinese Medicine, 130117, Changchun, China;Institute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No.5 BeiXianGe Street, Xicheng District, 100053, Beijing, China;Institute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No.5 BeiXianGe Street, Xicheng District, 100053, Beijing, China;Beijing University of Chinese Medicine, 100029, Beijing, China;Institute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No.5 BeiXianGe Street, Xicheng District, 100053, Beijing, China;Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, 100053, Beijing, China;

关键词: Diabetes mellitus;    Diabetic vascular complications;    Common mechanisms;    Endothelial dysfunction;    Secondary prevention;   

DOI  :  10.1186/s12964-022-01016-w

 received in 2022-10-26, accepted in 2022-12-11,  发布年份 2022

来源: Springer

【 摘 要 】

Diabetic vascular complications (DVCs), including macro- and micro- angiopathy, account for a high percentage of mortality in patients with diabetes mellitus (DM). Endothelial dysfunction is the initial and role step for the pathogenesis of DVCs. Hyperglycemia and lipid metabolism disorders contribute to endothelial dysfunction via direct injury of metabolism products, crosstalk between immunity and inflammation, as well as related interaction network. Although physiological and phenotypic differences support their specified changes in different targeted organs, there are still several common mechanisms underlying DVCs. Also, inhibitors of these common mechanisms may decrease the incidence of DVCs effectively. Thus, this review may provide new insights into the possible measures for the secondary prevention of DM. And we discussed the current limitations of those present preventive measures in DVCs research.AtQqCcZA72cRUWuc-5MhGdVideo Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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