Perspectives for therapeutic HPV vaccine development

Journal of Biomedical Science

Review

Emily Farmer¹  Andrew Yang¹  T. C. Wu²  Chien-Fu Hung³ 

[1] Department of Pathology, Johns Hopkins University, Baltimore, MD, USA;Department of Pathology, Johns Hopkins University, Baltimore, MD, USA;Department of Obstetrics and Gynecology, Johns Hopkins University, Baltimore, MD, USA;Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD, USA;Department of Oncology, Johns Hopkins University, Baltimore, MD, USA;Department of Pathology, Johns Hopkins University, Baltimore, MD, USA;Department of Oncology, Johns Hopkins University, Baltimore, MD, USA;The Johns Hopkins University School of Medicine, CRB II Room 307, 1550 Orleans Street, 21231, Baltimore, MD, USA;

关键词: Human papillomavirus;    HPV;    Therapeutic vaccine;    Cervical cancer;    HPV E6;    HPV E7;   

DOI  :  10.1186/s12929-016-0293-9

 received in 2016-10-12, accepted in 2016-10-26,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundHuman papillomavirus (HPV) infections and associated diseases remain a serious burden worldwide. It is now clear that HPV serves as the etiological factor and biologic carcinogen for HPV-associated lesions and cancers. Although preventative HPV vaccines are available, these vaccines do not induce strong therapeutic effects against established HPV infections and lesions. These concerns create a critical need for the development of therapeutic strategies, such as vaccines, to treat these existing infections and diseases.Main BodyUnlike preventative vaccines, therapeutic vaccines aim to generate cell-mediated immunity. HPV oncoproteins E6 and E7 are responsible for the malignant progression of HPV-associated diseases and are consistently expressed in HPV-associated diseases and cancer lesions; therefore, they serve as ideal targets for the development of therapeutic HPV vaccines. In this review we revisit therapeutic HPV vaccines that utilize this knowledge to treat HPV-associated lesions and cancers, with a focus on the findings of recent therapeutic HPV vaccine clinical trials.ConclusionGreat progress has been made to develop and improve novel therapeutic HPV vaccines to treat existing HPV infections and diseases; however, there is still much work to be done. We believe that therapeutic HPV vaccines have the potential to become a widely available and successful therapy to treat HPV and HPV-associated diseases in the near future.

【 授权许可】

CC BY   
© The Author(s). 2016