Renal abnormalities among HIV infected children at Muhimbili National Hospital (MNH)—Dar es Salaam, Tanzania

BMC Nephrology

Research Article

Eden E. Maro¹  Francis Fredrick²  Joel M. Francis³  Paschal J. Ruggajo⁴ 

[1] Department of Internal Medicine, School of Medicine, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania;Department of Paediatrics and Child Health, School of Medicine, Muhimbili University of Health and Allied Sciences (MUHAS), P. O. Box 65001, Dar es Salaam, Tanzania;Renal Unit, Muhimbili National Hospital (MNH), Dar es Salaam, Tanzania;National Institute of Medical Research (NIMR), Mwanza-Centre, Mwanza, Tanzania;Renal Unit, Muhimbili National Hospital (MNH), Dar es Salaam, Tanzania;Department of Internal Medicine, School of Medicine, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania;

关键词: Proteinuria;    Severe Renal Impairment;    Renal Complication;    Muhimbili National Hospital;    Cortical Echogenicity;   

DOI  :  10.1186/s12882-016-0242-6

 received in 2015-01-29, accepted in 2016-03-16,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundHuman Immunodeficiency Virus infection is a multisystem disease that contributes to significant morbidity. Renal involvement is reported to be common among patients with HIV. This study was carried out to determine renal involvement using simple bedside tests combined with ultrasonography examination.MethodsWe recruited 240 children from the HIV clinic at Muhimbili National Hospital. Data were collected using structured questionnaires and included demographic, clinical information, radiological tests; renal ultrasound and laboratory tests; serum creatinine, white blood cells, CD4+ counts and percent, urine for microalbuminuria and proteinuria.ResultsMicroalbuminuria and proteinuria were present in 20.4 % and 7.1 % respectively. Significantly higher prevalence of microalbuminuria (p < 0.01) and proteinuria p < 0.01) were noted with low CD4 percent (<25 %). Lower mean CD4+ count were noted among children with microalbuminuria [937.4 ± 595.3 cells/μL vs 1164.7 ± 664.3 cell/μL, (p < 0.05)] and proteinuria [675.5 ± 352.3 cells/μL vs 1152 ± 662 cells/μL (p < 0.001)]. Fourteen (5.8 %) HIV infected children had estimated glomerular filtration rate (eGFR of 30–59) consistent with severe renal impairment. Increased cortical echogenicity was noted in 69/153 (39.2 %) of participants who had ultrasound examination.ConclusionMicroalbuminuria, proteinuria and renal dysfunction were noted to be prevalent among HIV infected children indicating the need to consider routine screening of renal complications in these children.

【 授权许可】

CC BY   
© Fredrick et al. 2016