Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity

Nutrition Journal

Research

Tze Ping Loh¹  Shao Feng Mok²  Yvonne Teo³  Sonia Baig³  Muhammad Shabeer³  Ehsan Parvaresh Rizi⁴  E. Shyong Tai⁵  Chin Meng Khoo⁵  Sue-Anne Toh⁶  Faidon Magkos⁷  Antonio Vidal-Puig⁸  Sam Virtue⁸ 

[1] Department of Laboratory Medicine, National University Health System, Singapore, Singapore;Department of Medicine, National University Health System, Singapore, Singapore;Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, 117599, Singapore, Singapore;Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, 117599, Singapore, Singapore;Department of Medicine, National University Health System, Singapore, Singapore;Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, 117599, Singapore, Singapore;Department of Medicine, National University Health System, Singapore, Singapore;DUKE-National University of Singapore Medical School, Singapore, Singapore;Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, 117599, Singapore, Singapore;Department of Medicine, National University Health System, Singapore, Singapore;DUKE-National University of Singapore Medical School, Singapore, Singapore;Perelman School of Medicine, University of Pennsylvania, Pennsylvania, USA;Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;Singapore Institute of Clinical Sciences (SICS), A*STAR, Singapore, Singapore;University of Cambridge Metabolic Research Laboratories, Cambridge, UK;

关键词: Mononuclear cells;    Inflammation;    Gene expression;    Diet;    Macronutrients;   

DOI  :  10.1186/s12937-016-0219-0

 received in 2016-08-21, accepted in 2016-11-24,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundObesity-related insulin resistance is linked to inflammation. Immunometabolic function differs between lean and obese subjects, but whether macronutrient composition of ingested meals affects these responses is not well known. We examined the effects of a single meal rich in fat, protein, or carbohydrate on immunometabolic responses.MethodsNine lean insulin sensitive (LIS) men and 9 obese insulin resistant (OIR) men ingested high-carbohydrate (HC), high-fat (HF) or high-protein (HP) mixed meals in random order. We assessed plasma glucose, insulin, and cytokine responses and cytokine gene expression in circulating mononuclear cells (MNC) at fasting and postprandial states (up to 6-h).ResultsExpression of NF-κB and TNFα genes were greater; whereas that of TGFβ and IL-6 genes were lower, in the OIR compared to the LIS individuals. The differences were significantly greater after the HC meal, but not after the HP or HF meal. Similar results were obtained for plasma concentrations of TNFα and IL-6.ConclusionsOur findings indicate that a single HC meal has a distinct adverse effect on immunometabolic responses in the OIR individuals. The cumulative effect of such adverse responses to meals rich in carbohydrate may predispose the OIR individuals to a higher risk of cardiovascular disease.

【 授权许可】

CC BY   
© The Author(s). 2016