Novel role of immune-related non-coding RNAs as potential biomarkers regulating tumour immunoresponse via MICA/NKG2D pathway

Biomarker Research

Review

Quan Zhu¹  Xiaofang Lu¹  Manqing Peng¹  Yizhou Zou¹  Qizhi Luo¹  Junshuang Guo¹  Leiyan Wei¹  Xin Li¹  Zhiqing Xiang¹  Jing Zhang²  Chunlin Ou³ 

[1] Department of Immunology, School of Basic Medicine, Central South University, 410000, Changsha, Hunan, China;Department of Pathology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Department of Immunology, School of Basic Medicine, Central South University, 410000, Changsha, Hunan, China;Department of Pathology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410000, Changsha, Hunan, China;

关键词: MICA;    NKG2D;    circRNA;    lncRNA;    microRNA;    ceRNA;    Immunity;    Cancers;   

DOI  :  10.1186/s40364-023-00530-4

 received in 2023-04-02, accepted in 2023-09-24,  发布年份 2023

来源: Springer

【 摘 要 】

Major histocompatibility complex class I related chain A (MICA) is an important and stress-induced ligand of the natural killer group 2 member D receptor (NKG2D) that is expressed in various tumour cells. Given that the MICA/NKG2D signalling system is critically embedded in the innate and adaptive immune responses, it is particularly involved in the surveillance of cancer and viral infections. Emerging evidence has revealed the important roles of non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in different cancer types. We searched for all relevant publications in the PubMed, Scopus and Web of Science database using the keywords ncRNA, MICA, NKG2D, cancer, and miRNAs. All relevant studies published from 2008 to the 2023 were retrieved and collated. Notably, we found that miRNAs can target to NKG2D mRNA and MICA mRNA 3’-untranslated regions (3’-UTR), leading to translation inhibition of NKG2D and MICA degradation. Several immune-related MICA/NKG2D pathways may be dysregulated in cancer with aberrant miRNA expressions. At the same time, the competitive endogenous RNA (ceRNA) hypothesis holds that circRNAs, lncRNAs, and mRNAs induce an abnormal MICA expression by directly targeting downstream miRNAs to mediate mRNA suppression in cancer. This review summarizes the novel mechanism of immune escape in the ncRNA-related MICA/NKG2D pathway mediated by NK cells and cancer cells. Moreover, we identified the miRNA-NKG2D, miRNA-MICA and circRNA/lncRNA/mRNA-miRNA-mRNA/MICA axis. Thus, we were particularly concerned with the regulation of mediated immune escape in the MICA/NKG2D pathway by ncRNAs as potential therapeutic targets and diagnostic biomarkers of immunity and cancer.

【 授权许可】

CC BY   
© Yumed Inc. and BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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