Vibrio chromosomes share common history

BMC Microbiology

Research Article

Martin F Polz¹  Benjamin C Kirkup¹  LeeAnn Chang¹  Sarah Chang²  Dirk Gevers³ 

[1] Dept. of Civil and Environmental Engineering, 15 Vassar Street, 02139, Cambridge, MA, USA;Infectious Diseases, Childrens' Hospital Boston, 200 Longwood Ave., 02115, Boston, MA, USA;Microbial Sequencing Center, The Broad Institute of MIT and Harvard, 7 Cambridge Center, 02142, Cambridge, MA, USA;

关键词: Horizontal Gene Transfer;    Gene Content;    Single Copy Gene;    Vibrio Cholerae;    Cholerae Strain;   

DOI  :  10.1186/1471-2180-10-137

 received in 2009-08-27, accepted in 2010-05-10,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundWhile most gamma proteobacteria have a single circular chromosome, Vibrionales have two circular chromosomes. Horizontal gene transfer is common among Vibrios, and in light of this genetic mobility, it is an open question to what extent the two chromosomes themselves share a common history since their formation.ResultsSingle copy genes from each chromosome (142 genes from chromosome I and 42 genes from chromosome II) were identified from 19 sequenced Vibrionales genomes and their phylogenetic comparison suggests consistent phylogenies for each chromosome. Additionally, study of the gene organization and phylogeny of the respective origins of replication confirmed the shared history.ConclusionsThus, while elements within the chromosomes may have experienced significant genetic mobility, the backbones share a common history. This allows conclusions based on multilocus sequence analysis (MLSA) for one chromosome to be applied equally to both chromosomes.

【 授权许可】

CC BY   
© Kirkup et al; licensee BioMed Central Ltd. 2010