Video-assisted Thoracoscopic surgery (VATS) lobectomy for lung cancer does not induce a procoagulant state

Thrombosis Journal

Research

Søren Pedersen¹  Kåre Hornbech²  Thomas Decker Christensen³  Henrik Vad³  Peter B. Licht⁴  Anne-Mette Hvas⁵  Mads Nybo⁶  Nora Elisabeth Zois⁷ 

[1] Department of Anesthesiology and Intensive Care, Aarhus University Hospital, DK - 8200, Aarhus N, Denmark;Department of Clinical Medicine, Aarhus University Hospital, DK - 8200, Aarhus N, Denmark;Department of Cardio-thoracic Surgery, Rigshospitalet, Copenhagen University Hospital, DK - 2100, Copenhagen, Denmark;Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, DK - 8200, Aarhus N, Denmark;Department of Clinical Medicine, Aarhus University Hospital, DK - 8200, Aarhus N, Denmark;Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, DK - 5000, Odense C, Denmark;Department of Clinical Biochemistry, Aarhus University Hospital, DK - 8200, Aarhus N, Denmark;Department of Clinical Medicine, Aarhus University Hospital, DK - 8200, Aarhus N, Denmark;Department of Clinical Biochemistry, Odense University Hospital, DK - 5000, Odense C, Denmark;Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, DK - 2100, Copenhagen, Denmark;

关键词: Venous thrombosis;    Blood coagulation test;    Blood coagulation;    Lung neoplasm;    Thoracic surgery;    Video assisted;   

DOI  :  10.1186/s12959-017-0152-2

 received in 2017-09-15, accepted in 2017-12-11,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundChanges in the coagulation system in patients undergoing surgery for lung cancer have been sparsely investigated and the impact of the surgical trauma on the coagulation system is largely unknown in these patients. An increased knowledge could potentially improve the thromboprophylaxis regimes. The aim of this study was to assess the coagulation profile evoked in patients undergoing curative surgery by Video-Assisted Thoracoscopic Surgery (VATS) lobectomy for primary lung cancer.MethodsThirty-one patients diagnosed with primary lung cancer undergoing VATS lobectomy were prospectively included. The coagulation profile was assessed preoperatively and in the first two days postoperatively using a wide range of standard coagulation tests, dynamic whole blood coagulation measured by rotational thromboelastometry (ROTEM®) and thrombin generation evaluated by calibrated automated thrombography. Patients did not receive thromboprophylactic treatment. Data was analyzed using repeated measures one-way ANOVA.ResultsThe standard coagulation parameters displayed only subtle changes after surgery and the ROTEM® and thrombin generation results remained largely unchanged.ConclusionsPatients undergoing VATS lobectomy are normocoagulable in the preoperative state and a VATS lobectomy does not significantly influence the coagulation.Trial registrationThe trial is registered at ClinicalTrials.gov (Identifier: NCT01741506) and at EudraCTno. 2012–002409-23. Registered December 2012.

【 授权许可】

CC BY   
© The Author(s). 2017