A dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemical markers of health and adiposity

Lipids in Health and Disease

Research

Robert E Canale¹  Richard J Bloomer¹  Zach W Bell¹ 

[1] Cardiorespiratory/Metabolic Laboratory, The University of Memphis, 38152, Memphis, TN, USA;

关键词: Trolox Equivalent Antioxidant Capacity;    Physical Activity Program;    Hepatic Fatty Acid;    Glabridin;    Lipid Panel;   

DOI  :  10.1186/1476-511X-10-29

 received in 2011-01-04, accepted in 2011-02-10,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundLicorice flavonoid oil (LFO) has been reported to minimize visceral adipose tissue gain in obese mice and to result in a decrease in body weight and body fat in humans; the effects of which may be more pronounced when administered in an overfed state.MethodsWe investigated the effects of LFO in two separate studies. Study 1 included a sample of overweight or grade I-II obese men and women (N = 22) who followed their usual dietary and physical activity programs. Study 2 included a sample of athletic men who followed their usual dietary and physical activity programs but consumed a daily supplemental meal (25% above daily energy requirements) in an attempt to induce a state of overfeeding. In both studies, subjects were randomly assigned (double-blind) to either LFO or a placebo for eight weeks, and anthropometric and multiple biochemical outcomes (e.g., markers of oxidative stress, markers of insulin sensitivity, blood lipids, etc.) were obtained before and following the intervention.ResultsNo differences of statistical significance were noted between LFO and placebo for any measured variable in Study 1 or Study 2. When investigating the percent change from baseline for data in Study 2, although not of statistical significance, subjects in the LFO condition experienced less overall fat gain, as well as attenuation in the elevation in selected blood lipids (e.g., cholesterol, LDL-C, and triglycerides).ConclusionThese combined data indicate little effect of LFO supplementation within a sample of overweight/obese men and women or athletic men, with the possible exception of attenuation in body fat gain and selected components of the blood lipid panel in response to an overfeeding condition.

【 授权许可】

Unknown   
© Bell et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.