The higher exercise intensity and the presence of allele I of ACE gene elicit a higher post-exercise blood pressure reduction and nitric oxide release in elderly women: an experimental study

BMC Cardiovascular Disorders

Research Article

Vanessa N Oliveira¹  Foued S Espíndola¹  Otávio T Nóbrega²  Willson B Neto³  Herbert G Simões³  Marcelo M Sales³  Carmen SG Campbell³  Hugo AP Santana⁴  Carla B Silva⁵  Ricardo Y Asano⁶  Sérgio R Moreira⁷ 

[1] Instituto de Genética e Bioquímica da Universidade Federal de Uberlândia - UFU, Uberlândia, MG, Brazil;Programa de Pós-Graduação em Ciências Médicas e Programa de Pós -graduação em Ciências da Saúde, Universidade de Brasília - UnB, Brasília, DF, Brazil;Programa de Pós-graduação em Educação Física e Saúde, Universidade Católica de Brasília - UCB, Brasília, DF, Brazil;Programa de Pós-graduação em Educação Física e Saúde, Universidade Católica de Brasília - UCB, Brasília, DF, Brazil;Centro Universitário do Planalto de Araxá - UNIARAXÀ, Araxá-MG, Brazil;Programa de Pós-graduação em Educação Física e Saúde, Universidade Católica de Brasília - UCB, Brasília, DF, Brazil;Faculdade de Educação Física do Centro Anhanguera Educacional, Taguatinga, DF, Brazil;Programa de Pós-graduação em Educação Física e Saúde, Universidade Católica de Brasília - UCB, Brasília, DF, Brazil;Faculdade de Educação Física do Centro Universitário - UNIRG, Gurupi, TO, Brazil;Universidade Federal do Vale do São Francisco -UNIVASF, Petrolina, PE, Brazil;

关键词: Nitric Oxide;    Angiotensin Converting Enzyme;    Mean Arterial Pressure;    Exercise Session;    Blood Pressure Response;   

DOI  :  10.1186/1471-2261-11-71

 received in 2011-05-19, accepted in 2011-12-02,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe absence of the I allele of the angiotensin converting enzyme (ACE) gene has been associated with higher levels of circulating ACE, lower nitric oxide (NO) release and hypertension. The purposes of this study were to analyze the post-exercise salivary nitrite (NO2-) and blood pressure (BP) responses to different exercise intensities in elderly women divided according to their ACE genotype.MethodsParticipants (n = 30; II/ID = 20 and DD = 10) underwent three experimental sessions: incremental test - IT (15 watts workload increase/3 min) until exhaustion; 20 min exercise 90% anaerobic threshold (90% AT); and 20 min control session without exercise. Volunteers had their BP and NO2- measured before and after experimental sessions.ResultsDespite both intensities showed protective effect on preventing the increase of BP during post-exercise recovery compared to control, post-exercise hypotension and increased NO2- release was observed only for carriers of the I allele (p < 0.05).ConclusionGenotypes of the ACE gene may exert a role in post-exercise NO release and BP response.

【 授权许可】

Unknown   
© Santana et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.