Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model

BMC Anesthesiology

Research Article

Tomas Tyll¹  Pavel Dostal²  Zdenek Turek²  Islam Abdo²  David Astapenko²  Vlasta Dostalova²  Jitka Schreiberova²  Vlasta Dostalova²  Jiri Paral³  Miroslav Cihlo⁴ 

[1] Department of Anesthesia and Intensive Care Medicine, Charles University, 1st Faculty of Medicine Prague, Military University Hospital Prague, Prague, Czech Republic;Department of Anesthesia and Intensive Care Medicine, Charles University, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic;Department of Military Surgery, Faculty of Military Health Sciences, Hradec Kralove, University of Defence, Brno, Czech Republic;Department of Neurosurgery, Charles University, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic;

关键词: Brain;    Hypertonic saline;    Mannitol;    Microcirculation;    Osmotherapy;   

DOI  :  10.1186/s12871-015-0067-z

 received in 2014-12-21, accepted in 2015-05-28,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundHyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The aim of this animal study was to compare the short-term effects of equivolemic, equiosmolar solutions of mannitol and hypertonic saline (HTS) on cerebral cortical microcirculation in a rabbit craniotomy model.MethodsRabbits (weight, 2.0–3.0 kg) were anesthetized, ventilated mechanically, and subjected to a craniotomy. The animals were allocated randomly to receive a 3.75 ml/kg intravenous infusion of either 3.2 % HTS (group HTS, n = 8) or 20 % mannitol (group MTL, n = 8). Microcirculation in the cerebral cortex was evaluated using sidestream dark-field (SDF) imaging before and 20 min after the end of the 15-min HTS infusion. Global hemodynamic data were recorded, and blood samples for laboratory analysis were obtained at the time of SDF image recording.ResultsNo differences in the microcirculatory parameters were observed between the groups before the use of osmotherapy. After osmotherapy, lower proportions of perfused small vessel density (P = 0.0474), perfused vessel density (P = 0.0457), and microvascular flow index (P = 0.0207) were observed in the MTL group compared with those in the HTS group.ConclusionsOur findings suggest that an equivolemic, equiosmolar HTS solution better preserves perfusion of cortical brain microcirculation compared to MTL in a rabbit craniotomy model.

【 授权许可】

CC BY   
© Dostal et al. 2015