Vocal fold composition and early glottic carcinoma infiltration

World Journal of Surgical Oncology

Research

Guangbin Sun¹  Qin Fang¹  Na Sun¹  Xiaoyan Zhao²  Luhong Cao²  Lide Wu³  Xuejun Tan³  Yang Wang⁴ 

[1] Department of Otolaryngology, Gongli Hospital, 219 Miaopu Road, Pudong New Area, 200135, Shanghai, China;Department of Otolaryngology, Ningxia Medical University, 750004, Ningxia, China;Department of Otolaryngology, Wanzhou Shanghai hospital, 404000, Chongqing, China;Department of Pathology, Changhai Hospital, 200433, Shanghai, China;

关键词: Infiltration;    Laryngeal carcinomas;    Pathology;    Surgery;    Vocal fold;   

DOI  :  10.1186/1477-7819-10-178

 received in 2012-06-04, accepted in 2012-08-08,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundCurrent imaging techniques provide only limited information pertaining to the extent of infiltration of laryngeal carcinomas into vocal fold tissue layers. Therefore, it is needed to seek the contribute to the body of knowledge surrounding examination and characterization in laryngeal carcinoma infiltration.MethodsExcised larynges were collected from 30 male laryngectomy patients with an average age of 43.5 years (ranging 36 to 55 years) and history of smoking (≥10 years) exhibiting T1, T2, or subglottal (normal vocal fold) carcinomas. Vocal folds were preserved via freezing or immersion in paraffin. The depth of the mucosa, submucosa, and muscular layers in both normal vocal folds and tumor tissues of afflicted vocal folds was measured.ResultsThe average depths of the mucosa, submucosa, and muscular layers in normal vocal folds were 0.15 ± 0.06 mm, 2.30 ± 0.59 mm, and 2.87 ± 0.88 mm, respectively. Infiltration measurements of T1 tumors showed a depth of 1.62 ± 0.51 mm and 1.32 ± 0.49 mm in frozen sections and paraffin-embedded samples, respectively. Similarly, T2 tumors showed a depth of 2.87 ± 0.68 mm and 2.58 ± 0.67 mm in frozen sections and paraffin-embedded samples, respectively. T1 and T2 tumors occupied 24.8 ± 10 and 48.5 ± 15 percent of the normal vocal fold depth, respectively.ConclusionThis data provides a baseline for estimating infiltration of laryngeal carcinomas in vocal fold tissue layers, of particular interest to surgeons. This information may be used to assess typical depths of infiltration, thus allowing for more appropriate selection of surgical procedures based on individual patient assessment.

【 授权许可】

Unknown   
© Fang et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.