Ingested hyaluronan moisturizes dry skin

Nutrition Journal

Review

Osamu Urushibata¹  Takeshi Yamasaki²  Wataru Odanaka²  Wakako Sakamoto²  Ryosuke Matsuoka²  Toshihide Sato²  Yasunobu Masuda²  Chinatsu Kawada²  Takushi Yoshida²  Tomoyuki Kanemitsu²  Hideto Yoshida² 

[1] Department of Dermatology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-ku, Tokyo, Japan;R&D Division, Kewpie Corporation, 2-5-7, Sengawa-cho, Chofu-shi, Tokyo, Japan;

关键词: Hyaluronan;    Hyaluronic acid;    Ingestion;    Dry skin;    Moisturizing;   

DOI  :  10.1186/1475-2891-13-70

 received in 2014-03-26, accepted in 2014-07-08,  发布年份 2014

来源: Springer

【 摘 要 】

Hyaluronan (HA) is present in many tissues of the body and is essential to maintain moistness in the skin tissues, which contain approximately half the body’s HA mass. Due to its viscosity and moisturizing effect, HA is widely distributed as a medicine, cosmetic, food, and, recently marketed in Japan as a popular dietary supplement to promote skin moisture. In a randomized, double-blind, placebo-controlled clinical study it was found that ingested HA increased skin moisture and improved treatment outcomes for patients with dry skin. HA is also reported to be absorbed by the body distributed, in part, to the skin. Ingested HA contributes to the increased synthesis of HA and promotes cell proliferation in fibroblasts. These effects show that ingestion of HA moisturizes the skin and is expected to improve the quality of life for people who suffer from dry skin. This review examines the moisturizing effects of dry skin by ingested HA and summarizes the series of mechanisms from absorption to pharmacological action.

【 授权许可】

Unknown   
© Kawada et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.