Overexpression of Class III β-tubulin, Sox2, and nuclear Survivin is predictive of taxane resistance in patients with stage III ovarian epithelial cancer

BMC Cancer

Research Article

Yingli Fang¹  Xiuwen Wang¹  Yanguo Liu¹  Bei Li¹  Yang Wang¹  Wen Zhou¹  Jisheng Li¹  Jintong Du² 

[1] Department of Chemotherapy, Qilu Hospital of Shandong University, No. 107 Wenhuaxi road, 250012, Ji’nan, Shandong, China;Department of Chemotherapy, Qilu Hospital of Shandong University, No. 107 Wenhuaxi road, 250012, Ji’nan, Shandong, China;Shandong Cancer Hospital, Shandong Academy of Medical Science, 250012, Ji’nan, Shandong, China;

关键词: Ovarian cancer;    Class III β-tubulin;    Sox2;    Survivin;    Taxane;    Resistance;    Survival;   

DOI  :  10.1186/s12885-015-1553-x

 received in 2014-05-06, accepted in 2015-07-14,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundClass III β-tubulin, Sox2, and Survivin play important roles in tumor survival and proliferation. However, the association of these three factors with clinicopathological characteristics, chemoresistance, and survival in patients with ovarian cancer remains controversial.MethodsWe investigated the predictive value and correlation among the expression levels of Class III β-tubulin, Sox2, and Survivin in 110 patients with stage III ovarian epithelial cancer, including 58 patients who received taxane-based chemotherapy and 52 patients who received non-taxane-based chemotherapy. Expression of these three factors was immunohistochemically examined in 110 ovarian tumor tissues obtained from patients before chemotherapy.ResultsThe positive expression rates for Class III β-tubulin, Sox2, and Survivin in ovarian tumor tissues were 59.09 %, 61.82 % and 52.73 %, respectively. The expression of nuclear Survivin and Class III β-tubulin was consistent with that of Sox2 (p = 0.005 and 0.020, respectively). Positive expression of Class III β-tubulin, Sox2, and nuclear Survivin was significantly associated with chemoresistance to taxane-based chemotherapy (p = 0.006, 0.007, and 0.009, respectively), but not to non-taxane-based chemotherapy. Additionally, overexpression of Class III β-tubulin, Sox2, and nuclear Survivin predicted poor progression-free survival in patients receiving taxane-based chemotherapy (p = 0.032, 0.005, and 0.004, respectively).ConclusionsThese findings suggest that overexpression of Class III β-tubulin, Sox2, and nuclear Survivin might be predictive of taxane resistance and poor progression-free survival in patients with stage III ovarian epithelial cancer. Expression of these three factors may show positive correlations in these patients.

【 授权许可】

Unknown   
© Du et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.