Dynamics of double strand breaks and chromosomal translocations

Molecular Cancer

Review

Olga V Iarovaia¹  Elena Ioudinkova¹  Sergey V Razin²  Mikhail Rubtsov³  Tatiana Tsfasman⁴  Yegor S Vassetzky⁵ 

[1] Institute of Gene Biology, Russian Academy of Sciences, 117334, Moscow, Russia;LIA1066 « Laboratoire franco-russe de recherche en oncologie », Villejuif, France;Institute of Gene Biology, Russian Academy of Sciences, 117334, Moscow, Russia;LIA1066 « Laboratoire franco-russe de recherche en oncologie », Villejuif, France;Faculty of Biology, M.V. Lomonosov Moscow State University, 119992, Moscow, Russia;LIA1066 « Laboratoire franco-russe de recherche en oncologie », Villejuif, France;Faculty of Biology, M.V. Lomonosov Moscow State University, 119992, Moscow, Russia;UMR8126, Université Paris-Sud, CNRS, Institut de cancérologie Gustave Roussy, 94805, Villejuif, France;LIA1066 « Laboratoire franco-russe de recherche en oncologie », Villejuif, France;UMR8126, Université Paris-Sud, CNRS, Institut de cancérologie Gustave Roussy, 94805, Villejuif, France;LIA1066 « Laboratoire franco-russe de recherche en oncologie », Villejuif, France;Faculty of Biology, M.V. Lomonosov Moscow State University, 119992, Moscow, Russia;

关键词: Double Strand Break;    Damage Locus;    Mean Square Displacement;    Chromosomal Break;    Chromosomal Territory;   

DOI  :  10.1186/1476-4598-13-249

 received in 2014-08-06, accepted in 2014-10-30,  发布年份 2014

来源: Springer

【 摘 要 】

Chromosomal translocations are a major cause of cancer. At the same time, the mechanisms that lead to specific chromosomal translocations that associate different gene regions remain largely unknown. Translocations are induced by double strand breaks (DSBs) in DNA. Here we review recent data on the mechanisms of generation, mobility and repair of DSBs and stress the importance of the nuclear organization in this process.

【 授权许可】

Unknown   
© Iarovaia et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.