Impact of postoperative daily image-guided intensity-modulated radiotherapy on overall and local progression-free survival in patients with oral cavity cancer

BMC Cancer

Research Article

Yu-Chuen Huang¹  Wu-Chia Lo²  Li-Jen Liao²  Yu-Chin Lin³  Hui-Ju Tien⁴  Le-Jung Wu⁴  Chen-Hsi Hsieh⁵  Pei-Wei Shueng⁶  Li-Ying Wang⁷ 

[1] Department of Medical Research, China Medical University Hospital, Taichung, Taiwan;School of Chinese Medicine, China Medical University, Taichung, Taiwan;Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan;Division of Medical Oncology and Hematology, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan;Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, No.21, Sec. 2, Nanya S. Rd., Banciao Dist., 220, New Taipei City, Taiwan;Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, No.21, Sec. 2, Nanya S. Rd., Banciao Dist., 220, New Taipei City, Taiwan;Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan;Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan;Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, No.21, Sec. 2, Nanya S. Rd., Banciao Dist., 220, New Taipei City, Taiwan;Department of Radiation Oncology, National Defense Medical Center, Taipei, Taiwan;Oriental Institute of Technology, New Taipei City, Taiwan;School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan;Physical Therapy Center, National Taiwan University Hospital, Taipei, Taiwan;

关键词: Helical tomotherapy;    IGRT;    Image-guided;    Intensity-modulated radiation therapy;    Oral cavity cancer;   

DOI  :  10.1186/s12885-016-2165-9

 received in 2015-05-26, accepted in 2016-02-14,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundWe compared the outcome of patients who received non-image-guided intensity-modulated radiotherapy (IMRT) with those who received helical tomotherapy (HT), a daily image-guided radiotherapy (IGRT), after surgery for oral cavity cancer (OCC).MethodsDuring the period November 2006 to December 2013, a total of 152 postoperative OCC patients underwent either IMRT (n = 79) or daily IGRT (n = 73) 4 to 6 weeks after surgery. Patients in the IMRT group received 6 MV photon beams to 7 fields and those in the IGRT group received daily fractions of 1.8 or 2 Gy on five consecutive days.ResultsPatients who received daily IGRT had higher 5-year overall survival than those who received IMRT (87 % versus 48 %, p = 0.015). The local progression-free survival rate was also higher in patients who received IGRT (85 % versus 58 %, p = 0.006). More patients in the IGRT group completed the package of overall treatment time in ≤ 13 weeks and completed their course of radiation therapy in ≤ 8 weeks than patients in the IMRT group (89 % versus 68 %, p = 0.002; 84 % versus 58 %, p = 0.001), respectively. The rate of local failure in the primary tumor area was 24.0 % in the IMRT group and 6.8 % in the IGRT group. Among patients with primary local failure, the marginal failure rate was 52.6 % in the IMRT group and 0 % in the IGRT group.ConclusionsFor patients with locally advanced OCC, postoperative IGRT results in better overall survival, better local progression-free survival, less marginal failure and shorter overall treatment time than postoperative non-image-guided IMRT.

【 授权许可】

CC BY   
© Hsieh et al. 2016