Optical Nerve Detection by Diffuse Reflectance Spectroscopy for Feedback Controlled Oral and Maxillofacial Laser Surgery

Journal of Translational Medicine

Research

Werner Adler¹  Emeka Nkenke²  Florian Stelzle²  Alexandre Douplik³  Azhar Zam³  Katja Tangermann-Gerk⁴  Michael Schmidt⁵ 

[1] Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany;Department of Oral and Maxillofacial Surgery, Erlangen University Hospital, Erlangen, Germany;SAOT - Graduate School in Advanced Optical Technologies, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany;blz - Bavarian Laser Center, Erlangen, Germany;blz - Bavarian Laser Center, Erlangen, Germany;Chair of Photonic Technologies, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany;

关键词: Salivary Gland;    Cortical Bone;    Linear Discriminant Analysis;    Diffuse Reflectance;    Cancellous Bone;   

DOI  :  10.1186/1479-5876-9-20

 received in 2010-11-02, accepted in 2011-02-10,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundLaser surgery lacks haptic feedback, which is accompanied by the risk of iatrogenic nerve damage. It was the aim of this study to investigate diffuse reflectance spectroscopy for tissue differentiation as the base of a feedback control system to enhance nerve preservation in oral and maxillofacial laser surgery.MethodsDiffuse reflectance spectra of nerve tissue, salivary gland and bone (8640 spectra) of the mid-facial region of ex vivo domestic pigs were acquired in the wavelength range of 350-650 nm. Tissue differentiation was performed using principal component (PC) analysis followed by linear discriminant analysis (LDA). Specificity and sensitivity were calculated using receiver operating characteristic (ROC) analysis and the area under curve (AUC).ResultsFive PCs were found to be adequate for tissue differentiation with diffuse reflectance spectra using LDA. Nerve tissue could be differed from bone as well as from salivary gland with AUC results of greater than 88%, sensitivity of greater than 83% and specificity in excess of 78%.ConclusionsDiffuse reflectance spectroscopy is an adequate technique for nerve identification in the vicinity of bone and salivary gland. The results set the basis for a feedback system to prevent iatrogenic nerve damage when performing oral and maxillofacial laser surgery.

【 授权许可】

CC BY   
© Stelzle et al; licensee BioMed Central Ltd. 2011