Unexpectedly long half-lives of blood 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) levels in Yusho patients

Environmental Health

Research

Chikage Mitoma¹  Masutaka Furue¹  Hiroshi Uchi¹  Manabu Akahane²  Shinya Matsumoto²  Tomoaki Imamura²  Yoshiyuki Kanagawa²  Jumboku Kajiwara³ 

[1]Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan

[2]Department of Public Health, Health Management and Policy, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, Japan

[3]Fukuoka Institute of Health and Environmental Sciences, 39 Mukaizano, Dazaifu, Fukuoka, Japan

关键词: Yusho;    2,3,4,7,8-pentachlorodibenzofuran (PeCDF);    Half-life;    Dioxin;    Dioxin-like compounds;    Aging;   

DOI  :  10.1186/s12940-015-0059-y

 received in 2015-03-25, accepted in 2015-08-31,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundDioxins and dioxin-like compounds have half-lives typically between 7.2 years and 15 years. Our previous study of patients poisoned by extremely high concentrations of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) in the ‘Yusho incident’ in 1968 found that in some the half-life of blood 2,3,4,7,8-PeCDF tended towards infinity. This suggests that there are two groups of Yusho patients, those with 2,3,4,7,8-PeCDF half-lives around 10 years, and those with half-lives near infinity. We sought to establish the proportions of each in a cohort of 395 Yusho patients, and whether the proportions were changing over time.MethodsWe undertook longitudinal measurement of the blood concentration of 2,3,4,7,8-PeCDF in our cohort between 2002 and 2010. We estimated the change in concentration for each patient using linear regression for measured 2,3,4,7,8-PeCDF concentration, then compared the distribution of changes in concentrations with our previous study.ResultsIn patients in whom the blood concentration of 2,3,4,7,8-PeCDF exceeded 50 pg/g lipid, the proportion 8.0 % of patients exhibiting half-lives less than 13.3 years fell compared with our previous study (28.2 %), while the proportion with near infinity half-lives increased.ConclusionThe prolongation of the half-lives was likely a consequence of age-related factors.

【 授权许可】

CC BY   
© Matsumoto et al. 2015