Use of a modified GreenScreen tool to conduct a screening-level comparative hazard assessment of conventional silver and two forms of nanosilver

Environmental Health

Methodology

Nina Hwang¹  Jennifer Sass²  Lauren Heine³ 

[1] Green Seal, Washington, DC, USA;Natural Resources Defense Council and George Washington University Milken Institute School of Public Health, 1152 15th St NW, Suite 300, 20005, Washington DC, USA;Northwest Green Chemistry and Lauren Heine Group LLC, Spokane, WA, USA;

关键词: Nanomaterials;    Alternative assessment;    Hazard assessment;    Toxic chemicals;    Antimicrobials;    Nanosilver;    Silver;    Nanotechnology;   

DOI  :  10.1186/s12940-016-0188-y

 received in 2016-05-25, accepted in 2016-10-26,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundIncreased concern for potential health and environmental impacts of chemicals, including nanomaterials, in consumer products is driving demand for greater transparency regarding potential risks. Chemical hazard assessment is a powerful tool to inform product design, development and procurement and has been integrated into alternative assessment frameworks. The extent to which assessment methods originally designed for conventionally-sized materials can be used for nanomaterials, which have size-dependent physical and chemical properties, have not been well established. We contracted with a certified GreenScreen profiler to conduct three GreenScreen hazard assessments, for conventional silver and two forms of nanosilver. The contractor summarized publicly available literature, and used defined GreenScreen hazard criteria and expert judgment to assign and report hazard classification levels, along with indications of confidence in those assignments. Where data were not available, a data gap (DG) was assigned. Using the individual endpoint scores, an aggregated benchmark score (BM) was applied.ResultsConventional silver and low-soluble nanosilver were assigned the highest possible hazard score and a silica-silver nanocomposite called AGS-20 could not be scored due to data gaps. AGS-20 is approved for use as antimicrobials by the US Environmental Protection Agency.ConclusionsAn existing method for chemical hazard assessment and communication can be used – with minor adaptations– to compare hazards across conventional and nano forms of a substance. The differences in data gaps and in hazard profiles support the argument that each silver form should be considered unique and subjected to hazard assessment to inform regulatory decisions and decisions about product design and development. A critical limitation of hazard assessments for nanomaterials is the lack of nano-specific hazard data – where data are available, we demonstrate that existing hazard assessment systems can work. The work is relevant for risk assessors and regulators. We recommend that regulatory agencies and others require more robust data sets on each novel nanomaterial before granting market approval.

【 授权许可】

CC BY   
© The Author(s). 2016