Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus

Lipids in Health and Disease

Research

Marcela de Rezende Costa¹  Loyanne Francine Souza Magri¹  Daniela CU Cavallini¹  Camila Moroti¹  Katia Sivieri² 

[1] Department of Food & Nutrition, School of Pharmaceutical Sciences, São Paulo State University, Araraquara, SP, Brazil;Department of Food & Nutrition, School of Pharmaceutical Sciences, São Paulo State University, Araraquara, SP, Brazil;Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas, Departamento de Alimentos e Nutrição, Universidade Estadual, Caixa Postal 502, Rodovia Araraquara Jaú, Km 1, Campus Universitário, CEP 14802901, Araraquara, SP, Brazil;

关键词: Bifidobacterium bifidum;    Fructooligosaccharide;    Lactobacillus acidophilus;    Symbiotics;    Shake;   

DOI  :  10.1186/1476-511X-11-29

 received in 2012-01-06, accepted in 2012-02-22,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe consumption of foods containing probiotic and prebiotic ingredients is growing consistently every year, and in view of the limited number of studies investigating their effect in the elderly.ObjectiveThe objective of this study was to evaluate the effect of the consumption of a symbiotic shake containing Lactobacillus acidophilus, Bifidobacterium bifidum and fructooligosaccharides on glycemia and cholesterol levels in elderly people.MethodsA randomized, double-blind, placebo-controlled study was conducted on twenty volunteers (ten for placebo group and ten for symbiotic group), aged 50 to 60 years. The criteria for inclusion in the study were: total cholesterol > 200 mg/dL; triglycerides > 200 mg/dL and glycemia > 110 mg/dL. Over a total test period of 30 days, 10 individuals (the symbiotic group) consumed a daily dose of 200 mL of a symbiotic shake containing 108 UFC/mL Lactobacillus acidophilus, 108 UFC/mL Bifidobacterium bifidum and 2 g oligofructose, while 10 other volunteers (the placebo group) drank daily the same amount of a shake that did not contain any symbiotic bacteria. Blood samples were collected 15 days prior to the start of the experiment and at 10-day intervals after the beginning of the shake intake. The standard lipid profile (total cholesterol, triglycerides and HDL cholesterol) and glycemia, or blood sugar levels, were evaluated by an enzyme colorimetric assay.ResultsThe results of the symbiotic group showed a non-significant reduction (P > 0.05) in total cholesterol and triglycerides, a significant increase (P < 0.05) in HDL cholesterol and a significant reduction (P < 0.05) in fasting glycemia. No significant changes were observed in the placebo group.ConclusionThe consumption of symbiotic shake resulted in a significant increase in HDL and a significant decrease of glycemia.Trial RegistrationClinicalTrials.gov: NCT00123456

【 授权许可】

Unknown   
© Moroti et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.