Nanodiamonds protect skin from ultraviolet B-induced damage in mice

Journal of Nanobiotechnology

Research

Jen-Hung Yang¹  Po-Kong Chen²  Der-Shan Sun³  Hsin-Hou Chang⁴  Yu-Chung Lin⁵  Chia-Liang Cheng⁶  Meng-Si Wu⁷  Shih-Che Hung⁸ 

[1] Department of Biochemistry, School of Medicine, Tzu Chi University, No. 701 Sec. 3, Chung-Yang Rd, 970, Hualien City, Hualien County, Taiwan;Institute of Medical Sciences, School of Medicine, Tzu Chi University, No. 701 Sec. 3, Chung-Yang Rd, 970, Hualien City, Hualien County, Taiwan;Department of Dermatology, Buddhist Tzu Chi General Hospital, No. 707 Sec. 3, Chung-Yang Rd, 970, Hualien City, Hualien County, Taiwan;Department of Molecular Biology and Human Genetics, Tzu-Chi University, No. 701 Sec. 3, Chung-Yang Rd, 970, Hualien City, Hualien County, Taiwan;Department of Molecular Biology and Human Genetics, Tzu-Chi University, No. 701 Sec. 3, Chung-Yang Rd, 970, Hualien City, Hualien County, Taiwan;Institute of Medical Sciences, School of Medicine, Tzu Chi University, No. 701 Sec. 3, Chung-Yang Rd, 970, Hualien City, Hualien County, Taiwan;Department of Molecular Biology and Human Genetics, Tzu-Chi University, No. 701 Sec. 3, Chung-Yang Rd, 970, Hualien City, Hualien County, Taiwan;Research Center of Nanobiomedical Science, Tzu-Chi University, No. 701 Sec. 3, Chung-Yang Rd, 970, Hualien City, Hualien County, Taiwan;Nanotechnology Research Center, National Dong Hwa University, No. 1 Sec. 2, University Road, 974, Shoufeng Township, Hualien County, Taiwan;Institute of Medical Sciences, School of Medicine, Tzu Chi University, No. 701 Sec. 3, Chung-Yang Rd, 970, Hualien City, Hualien County, Taiwan;Department of Physics, National Dong Hwa University, No. 1 Sec. 2, University Road, 974, Shoufeng Township, Hualien County, Taiwan;Department of Physics, National Dong Hwa University, No. 1 Sec. 2, University Road, 974, Shoufeng Township, Hualien County, Taiwan;Nanotechnology Research Center, National Dong Hwa University, No. 1 Sec. 2, University Road, 974, Shoufeng Township, Hualien County, Taiwan;Division of Plastic Surgery, Department of Surgery, Buddhist Tzu Chi General Hospital, No. 707 Sec. 3, Chung-Yang Rd, 970, Hualien City, Hualien County, Taiwan;Department of Molecular Biology and Human Genetics, Tzu-Chi University, No. 701 Sec. 3, Chung-Yang Rd, 970, Hualien City, Hualien County, Taiwan;Institute of Medical Sciences, School of Medicine, Tzu Chi University, No. 701 Sec. 3, Chung-Yang Rd, 970, Hualien City, Hualien County, Taiwan;

关键词: Nanodiamonds;    Ultraviolet;    Sunburn;    Sunscreen;   

DOI  :  10.1186/s12951-015-0094-4

 received in 2015-01-11, accepted in 2015-04-29,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundSolar ultraviolet (UV) radiation causes various deleterious effects, and UV blockage is recommended for avoiding sunburn. Nanosized titanium dioxide and zinc oxide offer effective protection and enhance cosmetic appearance but entail health concerns regarding their photocatalytic activity, which generates reactive oxygen species. These concerns are absent in nanodiamonds (NDs). Among the UV wavelengths in sunlight, UVB irradiation primarily threatens human health.ResultsThe efficacy and safety of NDs in UVB protection were evaluated using cell cultures and mouse models. We determined that 2 mg/cm2 of NDs efficiently reduced over 95% of UVB radiation. Direct UVB exposure caused cell death of cultured keratinocyte, fibroblasts and skin damage in mice. By contrast, ND-shielding significantly protected the aforementioned pathogenic alterations in both cell cultures and mouse models.ConclusionsNDs are feasible and safe materials for preventing UVB-induced skin damage.

【 授权许可】

Unknown   
© Wu et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.