期刊论文

【摘要】

Genomic alterations may make cancer cells more dependent than normal cells on mechanisms of proteostasis, including protein folding and degradation. This proposition is the basis for the clinical use of proteasome inhibitors to treat multiple myeloma and mantle cell lymphoma. However, proteasome inhibitors have not proved effective in treating other cancers, and this has called into question the general applicability of this approach. Here, I consider possible explanations for this apparently limited applicability, and discuss whether inhibiting other broadly acting components of the ubiquitin-proteasome system - including ubiquitin-activating enzyme and the AAA-ATPase p97/VCP - might be more generally effective in cancer therapy.

【授权许可】

CC BY
© Deshaies; licensee BioMed Central Ltd. 2014

【预览】

附件列表
Files	Size	Format	View
RO202311108205762ZK.pdf	1815KB	PDF	download

【参考文献】

[1]
[2]
[3]
[4]
[5]
[6]
[7]
[8]
[9]
[10]
[11]
[12]
[13]
[14]
[15]
[16]
[17]
[18]
[19]
[20]
[21]
[22]
[23]
[24]
[25]
[26]
[27]
[28]
[29]
[30]
[31]
[32]
[33]
[34]
[35]
[36]
[37]
[38]
[39]
[40]
[41]
[42]
[43]
[44]
[45]
[46]
[47]
[48]
[49]
[50]
[51]
[52]
[53]
[54]
[55]
[56]
[57]
[58]
[59]
[60]
[61]
[62]
[63]
[64]
[65]
[66]
[67]
[68]
[69]
[70]
[71]
[72]
[73]
[74]
[75]
[76]
[77]
[78]
[79]
[80]
[81]
[82]
[83]
[84]
[85]
[86]
[87]
[88]
[89]
[90]
[91]
[92]
[93]
[94]
[95]
[96]
[97]
[98]
[99]
[100]
[101]
[102]
[103]
[104]
[105]
[106]
[107]
[108]
[109]
[110]
[111]
[112]
[113]
[114]
[115]
[116]
[117]
[118]
[119]
[120]
[121]
[122]
[123]

BMC Biology
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy
Review
Raymond J Deshaies¹
[1] Division of Biology and Biological Engineering and Howard Hughes Medical Institute, California Institute of Technology, 91107, Pasadena, CA, USA;
关键词: Multiple Myeloma; Bortezomib; Unfold Protein Response; Lenalidomide; Mantle Cell Lymphoma;
DOI : 10.1186/s12915-014-0094-0
来源: Springer
PDF


	文献评价指标
	下载次数：3次	浏览次数：0次

【 摘 要 】

【 授权许可】

【 预 览 】

【 参考文献 】

【摘要】

【授权许可】

【预览】

【参考文献】