Relationship of APOA5, PPARγ and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood

Lipids in Health and Disease

Research

Yogendra Singh¹  Ransi Abraham¹  Lakshmy Ramakrishnan¹  Harshpal S Sachdev²  Shikha Sinha²  Dileep Gupta²  Bhargava Santosh³  Seema Bhaskar⁴  Swami Prakash⁴  Giriraj R Chandak⁴  Meenakshi Sharma⁵  Kolli S Reddy⁶ 

[1] Department of Cardiac Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India;Department of Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research, New Delhi, India;Department of Pediatrics, Sunder Lal Jain Hospital, New Delhi, India;Genome Research Group, Centre for Cellular and Molecular Biology, Hyderabad, India;Non Communicable Disease Division, Indian Council of Medical Research, New Delhi, India;Public Health Foundation of India, New Delhi, India;

关键词: Birth Weight;    Minor Allele;    Standard Deviation Score;    Recessive Model;    Hepatic Lipase;   

DOI  :  10.1186/1476-511X-10-68

 received in 2011-02-05, accepted in 2011-05-08,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundTriglycerides is an independent risk factor for coronary artery disease (CAD) and is especially important in Indians because of high prevalence of hypertriglyceridemia in this population. Both genetic and environmental factors determine triglyceride levels. In a birth cohort from India, hypertriglyceridemia was found in 41% of men and 11% of women. Subjects who had high triglycerides had more rapid body mass index (BMI) or weight gain than rest of the cohort throughout infancy, childhood and adolescence. We analysed polymorphisms in APOA5, hepatic lipase and PPARγ genes and investigated their association with birth weight and serial changes in BMI.ResultsPolymorphisms in APOA5 (-1131T > C, S19W), PPARγ (Pro12Ala) and hepatic lipase (-514C > T) were studied by polymerase chain reaction (PCR) followed by restriction digestion in 1492 subjects from the New Delhi Birth Cohort (NDBC). We assessed whether these polymorphisms influence lipid and other variables and serial changes in BMI, both individually and together.The risk allele of APOA5 (-1131C) resulted in 23.6 mg/dl higher triglycerides as compared to normal allele (P < 0.001). Risk allele of HL (-514T) was associated with significantly higher HDL2 levels (P = 0.002). Except for the marginal association of PPARγ Pro12Ala variation with a lower conditional weight at 6 months, (P = 0.020) and APOA5 S19W with a higher conditional BMI at 11 yrs of age (P = 0.030), none of the other associations between the gene polymorphisms and serial changes in body mass index from birth to young adulthood were significant.ConclusionThe promoter polymorphism in APOA5 was associated with raised serum triglycerides and that of HL with raised HDL2 levels. None of the polymorphisms had any significant relationship with birth weight or serial changes in anthropometry from birth to adulthood in this cohort.

【 授权许可】

CC BY   
© Ramakrishnan et al; licensee BioMed Central Ltd. 2011