Haplotypes that include the integrin alpha 11 gene are associated with tick burden in cattle

BMC Genetics

Research Article

Kishore C Prayaga¹  Blair E Harrison¹  Rowan J Bunch¹  William Barendse¹  Laercio R Porto Neto² 

[1] Cooperative Research Centre for Beef Genetic Technologies, University of New England, 2351, Armidale, NSW, Australia;CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, 4067, St. Lucia, QLD, Australia;Cooperative Research Centre for Beef Genetic Technologies, University of New England, 2351, Armidale, NSW, Australia;CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, 4067, St. Lucia, QLD, Australia;The University of Queensland, School of Animal Studies, 4072, St. Lucia, QLD, Australia;

关键词: Taurine;    Single Nucleotide Polymorphism;    Tick Infestation;    Breed Type;    Single Nucleotide Polymorphism Marker;   

DOI  :  10.1186/1471-2156-11-55

 received in 2009-10-13, accepted in 2010-06-21,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundInfestations on cattle by the ectoparasite Boophilus (Rhipicephalus) microplus (cattle tick) impact negatively on animal production systems. Host resistance to tick infestation has a low to moderate heritability in the range 0.13 - 0.64 in Australia. Previous studies identified a QTL on bovine chromosome 10 (BTA10) linked to tick burden in cattle.ResultsTo confirm these associations, we collected genotypes of 17 SNP from BTA10, including three obtained by sequencing part of the ITGA11 (Integrin alpha 11) gene. Initially, we genotyped 1,055 dairy cattle for the 17 SNP, and then genotyped 557 Brahman and 216 Tropical Composite beef cattle for 11 of the 17 SNP. In total, 7 of the SNP were significantly (P < 0.05) associated with tick burden tested in any of the samples. One SNP, ss161109814, was significantly (P < 0.05) associated with tick burden in both the taurine and the Brahman sample, but the favourable allele was different. Haplotypes for three and for 10 SNP were more significantly (P < 0.001) associated with tick burden than SNP analysed individually. Some of the common haplotypes with the largest sample sizes explained between 1.3% and 1.5% of the residual variance in tick burden.ConclusionsThese analyses confirm the location of a QTL affecting tick burden on BTA10 and position it close to the ITGA11 gene. The presence of a significant association in such widely divergent animals suggests that further SNP discovery in this region to detect causal mutations would be warranted.

【 授权许可】

Unknown   
© Porto Neto et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.