Neoadjuvant imatinib treatment and laparoscopic anus-preserving surgery for a large gastrointestinal stromal tumor of the rectum

World Journal of Surgical Oncology

Case Report

Kenji Koda¹  Kazuya Shinmura²  Hidetaro Yokoyama³  Kazuya Okamoto³  Masaki Azuma³  Takahiro Shimamura³  Motoaki Shirakawa³  Kennoki Kyo³  Motohiro Nishiyama³  Toshio Nakamura³  Atsushi Maema³  Hitoshi Kanamaru³ 

[1] Department of Pathology, Fujieda Municipal General Hospital, 4-1-11 Surugadai, 426-8677, Fujieda, Shizuoka, Japan;Department of Pathology, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, 431-3192, Hamamatsu, Shizuoka, Japan;Department of Surgery, Fujieda Municipal General Hospital, 4-1-11 Surugadai, 426-8677, Fujieda, Shizuoka, Japan;

关键词: Gastrointestinal stromal tumor;    Neoadjuvant treatment;    Rectum;    Imatinib;    Laparoscopic surgery;   

DOI  :  10.1186/s12957-016-0837-1

 received in 2015-07-08, accepted in 2016-03-04,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundResection of a gastrointestinal stromal tumor (GIST) of the rectum can be difficult because of the particular location in the pelvis, and a large rectal GIST often requires abdominoperineal resection. Recent reports demonstrate that neoadjuvant imatinib treatment improves surgical outcomes in patients with a rectal GIST, and there are only a few reports of the effectiveness of laparoscopic surgery for a rectal GIST.Case presentationA 46-year-old man was found to have a rectal GIST that measured 80 mm and was located on the anterior wall of the lower rectum. After 6 months treatment with imatinib, the tumor decreased in size to 37 mm, and laparoscopic low anterior resection was performed. The patient is currently alive without any evidence of recurrence 37 months after surgery.ConclusionsNeoadjuvant imatinib should be a treatment of choice for a large rectal GIST. When marked tumor shrinkage is achieved, laparoscopic surgery may be the preferred procedure.

【 授权许可】

CC BY   
© Kyo et al. 2016