The maximum standardized uptake value of 18 F-FDG PET scan to determine prognosis of hormone-receptor positive metastatic breast cancer

BMC Cancer

Research Article

Bi-Yun Wang¹  Zhong-Hua Wang¹  Xi-Chun Hu¹  Jian Zhang¹  Zhen Jia¹  Gang Li²  Yong-Ping Zhang³  Min Zhou³  Ying-Jian Zhang³  Joseph Ragaz⁴ 

[1] Department of Medical Oncology, Department of Oncology, Fudan University Shanghai Cancer Center; Shanghai Medical College, Fudan University, Shanghai, China;Department of Medical Oncology, Fudan University Shanghai Cancer Center Minhang Branch, Fudan University, Shanghai, China;Department of Nuclear Medicine, Department of Oncology, Fudan University Shanghai Cancer Center; Shanghai Medical College, Fudan University, Shanghai, China;Faculty of Medicine, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada;

关键词: Metastatic breast cancer;    Luminal subtype;    PET/CT;    SUVmax;    Prognosis;   

DOI  :  10.1186/1471-2407-13-42

 received in 2012-10-30, accepted in 2013-01-30,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundWhether PET scan maximum standard uptake value (SUVmax) could differentiate luminal A from luminal B and help predict the survival of metastatic breast cancer (MBC) patients with luminal subtype is still unknown and need to be investigated.Methods305 MBC patients with luminal subtypes were screened with PET/CT. Eligible patients were prospectively followed up.ResultsIn total, 134 patients were eligible for this study. SUVmax was significantly related to the number of metastatic sites and presence of visceral metastasis on univariate analysis. SUVmax could not effectively differentiate patients with luminal A from luminal B subtype. Although luminal subtype at diagnosis could predict the relapse-free interval, it could not predict progression-free survival (PFS) or overall survival (OS) after developing relapse. In contrast, SUVmax was predictive of both PFS and OS and this effect was maintained in multivariate COX regression model.ConclusionsSUVmax of MBC did not correlate with molecular subtypes of primary tumor. While molecular subtype may be a valuable prognostic factor at primary diagnosis of breast cancer, the SUVmax, rather than molecular subtype, does have a potential to predict independently in multivariate analysis for the PFS and OS in patients with metastatic disease of luminal subtype.

【 授权许可】

Unknown   
© Zhang et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.