Comparing serum levels of cardiac biomarkers in cancer patients receiving chemotherapy and subjects with chronic periodontitis

Journal of Translational Medicine

Proceedings

Jin-le Li¹  Lan-jun Bai¹  Ye Tian¹  Yi-ding Dou²  Mary NB Cheung³  Yuan Yue⁴  Min Wang⁴  Hao Liang⁴  Chang-bin Fan⁵  Liu Qing⁶  Louis WC Chow⁶  Wings TY Loo⁷ 

[1] Department of Stomatology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan Province, P.R. China;Jin Hua Dentistry, 610041, Chengdu, Sichuan Province, P.R. China;Jin Hua Dentistry, 610041, Chengdu, Sichuan Province, P.R. China;Keenlink Dental Clinic, Hong Kong, SAR;State Key Laboratory for Oral Diseases and Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Sichuan, PR China;Stomatological Hospital of Guangzhou Medical College, Guangzhou, PR China;UNIMED Medical Institute, Hong Kong, SAR;UNIMED Medical Institute, Hong Kong, SAR;School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR;

关键词: Coronary Heart Disease;    Periodontitis;    Brain Natriuretic Peptide;    Invasive Ductal Carcinoma;    Chronic Periodontitis;   

DOI  :  10.1186/1479-5876-10-S1-S5

来源: Springer

【 摘 要 】

BackgroundChronic periodontitis (CP) is a chronic inflammation associated with elevations of several inflammatory and cardiac markers. Studies implicated CP as one of the etiologies in coronary heart disease (CHD). Cardiotoxicity is a major complication of anticancer drugs, including anthracyclines and 5-fluorouracil (5FU). The most severe cardiac complications are heart failure, arrhythmia and coronary heart disease (CHD). In this study, we compared the level of inflammatory factors and cardiac markers between chronic periodontitis patients and cancer patients receiving chemotherapy.Methods108 blood samples of periodontally healthy subjects were obtained on random from Hong Kong Red Cross, and these represented the controlled population. Forty-four patients diagnosed with chronic periodontitis were recruited from the West China Hospital of Stomatology, Sichuan University. They have received scaling and root planning with mean pocket depths of 6.05 mm. Thirty breast cancer patients diagnosed with invasive ductal carcinoma from UNIMED Medical Institute, Hong Kong gave consent to participate in this study. They received 4 cycles of 500mg/m2 5-fluorouracil, 75 mg/m2 epirubicin and 500mg/m2 cyclophosphamide at a 3-week interval between each cycle. Peripheral venous blood from each group was taken for measurement of blood cells, inflammatory marker (P-selectin, high sensitvity C-reactive protein) and cardiac markers (troponin T; troponin I; N-terminal pro brain natriuretic peptide (Nt-proBNP) and Lactate dehydrogenase (LDH).ResultsThe lymphocyte count was higher (p < 0.05) in periodontitis patients than the other two groups, and more neutrophils (p < 0.05) were seen in cancer patients receiving chemotherapy. The two test groups demonstrated higher levels (p < 0.01) of inflammatory and cardiac markers than the control group.ConclusionsThe elevated cardiac markers found in periodontitis patients suggested that they may carry potential risks in developing cardiac lesions. Troponin T, troponin I, pro-BNP, LDH and high sensitvity C-reactive protein may be used as markers to monitor cardiac lesions in chronic inflammatory patients.

【 授权许可】

Unknown   
© Loo et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.