A scaling aneurysm model-based approach to assessing the role of flow pattern and energy loss in aneurysm rupture prediction

Journal of Translational Medicine

Research

Xinjian Yang¹  Zhizheng Zhuo²  Qianqian Meng²  Haiyun Li²  Jingru Zhong³  Yunling Long³  Hongyu Yu³  Huagang Yan³ 

[1] Beijing Neurosurgical Institute, Beijing Tiantan Hospital, 100050, Beijing, China;Department of Biomedical Engineering, School of Biomedical Engineering, Capital Medical University, Fengtai District, 100069, Beijing, China;Department of Biomedical Engineering, School of Biomedical Engineering, Capital Medical University, Fengtai District, 100069, Beijing, China;Beijing Neurosurgical Institute, Beijing Tiantan Hospital, 100050, Beijing, China;

关键词: Intracranial aneurysm;    Aspect ratio;    Energy loss;    Fluid–structure interaction;    Flow pattern;   

DOI  :  10.1186/s12967-015-0673-z

 received in 2014-11-02, accepted in 2015-09-14,  发布年份 2015

来源: Springer

【 摘 要 】

Background and purposeEnergy loss (EL) was regarded to be one of the key parameters in predicting the rupture risk of IA. In this paper, we took varied aspect ratio (AR) as a scaling law to create a series of longitudinal models to investigate the longitudinal changes of flow pattern and EL as the AR varies, in order to explore the relationship between the longitudinal characteristic EL parameters with aneurysm rupture risk.MethodsSeven original intracranial aneurysms (IA) models with similar locations were reconstructed from patient 3D rotational angiography (3DRA) images. Based on these models, a series of scaling aneurysm models with different ARs were created with our proposed scaling algorithms. Fluid–solid interaction (FSI) simulations were performed on every model to obtain hemodynamics flow pattern and EL.ResultsWith AR increasing, flow pattern became more complex, with vortices appearing gradually in the aneurysms (AR > 1.5). Furthermore, the velocity significantly decreased in aneurysms with high ARs (>1.5). Meanwhile, the aneurysm EL increased with increasing AR. Once AR exceeded 1.5, EL changed drastically.ConclusionEL was a potential parameter predicting future rupture of unruptured aneurysms. If the EL during the growth of the unruptured aneurysms increased sharply, we strongly recommend an intervention.

【 授权许可】

CC BY   
© Long et al. 2015

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