Prevalence of peripheral arterial disease in patients at non-high cardiovascular risk. Rationale and design of the PANDORA study

BMC Cardiovascular Disorders

Study Protocol

Serge Kownator¹  Claudio Cimminiello²  Jean Claude Wautrecht³  Beat Kindler⁴  Christos P Carvounis⁵  Claudio Borghi⁶  Mario Mangrella⁷  Stefanus E Kranendonk⁸ 

[1] Clinique Ambroise Paré, Cardiology Department, Thionville, France;Department of Medicine, Vimercate Hospital, via Cesare Battisti 23, 20059, Vimercate, (MI), Italy;Department of Vascular Diseases, Hôpital Erasme, Brussels, Belgium;General Practitioner, Dufourstrasse 77, 8008, Zurich, Switzerland;Internal Medicine Department, Blue Cross Hospital, Athens, Greece;Internal Medicine Unit, University Hospital Sant'Orsola-Malpighi, Bologna, Italy;R&D Department, AstraZeneca SpA, Milan, Italy;TweeSteden Hospital, Dr Deelenlaan 5, 5042, Tilburg, AD, The Netherlands;

关键词: Peripheral Arterial Disease;    Peripheral Arterial Disease Patient;    Coronary Heart Disease Risk Equivalent;    Overt Cardiovascular Disease;    Asymptomatic Peripheral Arterial Disease;   

DOI  :  10.1186/1471-2261-10-35

 received in 2010-04-19, accepted in 2010-08-05,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundLower extremity peripheral arterial disease (PAD) is a marker of widespread atherosclerosis. Individuals with PAD, most of whom do not show typical PAD symptoms ('asymptomatic' patients), are at increased risk of cardiovascular ischaemic events. American College of Cardiology/American Heart Association guidelines recommend that individuals with asymptomatic lower extremity PAD should be identified by measurement of ankle-brachial index (ABI). However, despite its associated risk, PAD remains under-recognised by clinicians and the general population and office-based ABI detection is still poorly-known and under-used in clinical practice. The Prevalence of peripheral Arterial disease in patients with a non-high cardiovascular disease risk, with No overt vascular Diseases nOR diAbetes mellitus (PANDORA) study has a primary aim of assessing the prevalence of lower extremity PAD through ABI measurement, in patients at non-high cardiovascular risk, with no overt cardiovascular diseases (including symptomatic PAD), or diabetes mellitus. Secondary objectives include documenting the prevalence and treatment of cardiovascular risk factors and the characteristics of both patients and physicians as possible determinants for PAD under-diagnosis.Methods/DesignPANDORA is a non-interventional, cross-sectional, pan-European study. It includes approximately 1,000 primary care participating sites, across six European countries (Belgium, France, Greece, Italy, The Netherlands, Switzerland). Investigator and patient questionnaires will be used to collect both right and left ABI values at rest, presence of cardiovascular disease risk factors, current pharmacological treatment, and determinants for PAD under-diagnosis.DiscussionThe PANDORA study will provide important data to estimate the prevalence of asymptomatic PAD in a population otherwise classified at low or intermediate risk on the basis of current risk scores in a primary care setting.Trial registration numberClinical Trials.gov Identifier: NCT00689377.

【 授权许可】

CC BY   
© Cimminiello et al; licensee BioMed Central Ltd. 2010