Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage

Malaria Journal

Research

Florent Soubrier¹  Nadine N'dilimabaka²  Issam Arrouss²  Angelita Rebollo²  Dominique Mazier³  Paco Pino⁴  Serge Assi⁵  Zacharie Taoufiq⁶ 

[1] INSERM, UMR S525, Université Pierre et Marie Curie-Paris 6, Paris, France;INSERM, UMR S945, Université Pierre et Marie Curie-Paris 6, CHU-Pitié-Salpêtrière, 91 bd de l'Hôpital, 75013, Paris, France;INSERM, UMR S945, Université Pierre et Marie Curie-Paris 6, CHU-Pitié-Salpêtrière, 91 bd de l'Hôpital, 75013, Paris, France;AP-HP, Groupe hospitalier Pitié-Salpêtrière, Service Parasitologie-Mycologie, Paris, France;INSERM, UMR S945, Université Pierre et Marie Curie-Paris 6, CHU-Pitié-Salpêtrière, 91 bd de l'Hôpital, 75013, Paris, France;Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland;INSERM, UMR S945, Université Pierre et Marie Curie-Paris 6, CHU-Pitié-Salpêtrière, 91 bd de l'Hôpital, 75013, Paris, France;Institut Pierre Richet/Institut National de la Sante Publique, Abidjan, Ivory Coast;INSERM, UMR S945, Université Pierre et Marie Curie-Paris 6, CHU-Pitié-Salpêtrière, 91 bd de l'Hôpital, 75013, Paris, France;Okinawa Institute of Science and Technology, Onna, Okinawa, Japan;

关键词: Malaria;    Atorvastatin;    Cerebral Malaria;    Evans Blue;    Artesunate;   

DOI  :  10.1186/1475-2875-10-52

 received in 2010-11-30, accepted in 2011-02-28,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe adhesion of Plasmodium falciparum parasitized red blood cell (PRBC) to human endothelial cells (EC) induces inflammatory processes, coagulation cascades, oxidative stress and apoptosis. These pathological processes are suspected to be responsible for the blood-brain-barrier and other organs' endothelial dysfunctions observed in fatal cases of malaria. Atorvastatin, a drug that belongs to the lowering cholesterol molecule family of statins, has been shown to ameliorate endothelial functions and is widely used in patients with cardiovascular disorders.MethodsThe effect of this compound on PRBC induced endothelial impairments was assessed using endothelial co-culture models.ResultsAtorvastatin pre-treatment of EC was found to reduce the expression of adhesion molecules and P. falciparum cytoadherence, to protect cells against PRBC-induced apoptosis and to enhance endothelial monolayer integrity during co-incubation with parasites.ConclusionsThese results might suggest a potential interest use of atorvastatin as a protective treatment to interfere with the pathophysiological cascades leading to severe malaria.

【 授权许可】

CC BY   
© Taoufiq et al; licensee BioMed Central Ltd. 2011