Variations in atherosclerosis and remodeling patterns in aorta and carotids

Journal of Cardiovascular Magnetic Resonance

Research

John E Postley¹  Valentin Fuster²  Katsumi Hayashi³  Silvia Aguiar³  Ajay Nemade³  Venkatesh Mani³  Zahi A Fayad⁴ 

[1] College of Physicians and Surgeons, Columbia University, New York, NY, USA;Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA;Imaging Science Laboratories, Translational and Molecular imaging Institute, Department of Radiology, Mount Sinai School of Med, New York, NY, USA;Imaging Science Laboratories, Translational and Molecular imaging Institute, Department of Radiology, Mount Sinai School of Med, New York, NY, USA;Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA;

关键词: Carotid Artery;    Cardiovascular Magnetic Resonance;    Abdominal Aorta;    Statin Therapy;    Thoracic Aorta;   

DOI  :  10.1186/1532-429X-12-10

 received in 2009-08-10, accepted in 2010-03-05,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundAtherosclerosis is a progressive disease that causes vascular remodeling that can be positive or negative. The evolution of arterial wall thickening and changes in lumen size under current "standard of care" in different arterial beds is unclear. The purpose of this study was to examine arterial remodeling and progression/regression of atherosclerosis in aorta and carotid arteries of individuals at risk for atherosclerosis normalized over a 1-year period.MethodsIn this study, 28 patients underwent at least 2 black-blood in vivo cardiovascular magnetic resonance (CMR) scans of aorta and carotids over a one-year period (Mean 17.8 ± 7.5 months). Clinical risk profiles for atherosclerosis and medications were documented and patients were followed by their referring physicians under current "standard of care" guidelines. Carotid and aortic wall lumen areas were matched across the time-points from cross-sectional images.ResultsThe wall area increased by 8.67%, 10.64%, and 13.24% per year (carotid artery, thoracic aorta and abdominal aorta respectively, p < 0.001). The lumen area of the abdominal aorta increased by 4.97% per year (p = 0.002), but the carotid artery and thoracic aorta lumen areas did not change significantly. The use of statin therapy did not change the rate of increase of wall area of carotid artery, thoracic and abdominal aorta, but decreased the rate of change of lumen area of carotid artery (-3.08 ± 11.34 vs. 0.19 ± 12.91 p < 0.05).ConclusionsResults of this study of multiple vascular beds indicated that different vascular locations exhibited varying progression of atherosclerosis and remodeling as monitored by CMR.

【 授权许可】

Unknown   
© Hayashi et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.