Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy

BMC Cancer

Research Article

Xiaoxiang Guan¹  Qingyi Wei¹  Zhensheng Liu¹  Li-E Wang¹  Ming Yin¹  Hui Zhao¹  Xianglin Yuan²  Ritsuko Komaki²  Michael S O'Reilly²  Zhongxing Liao² 

[1] Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, Texas, USA;Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, Texas, USA;

关键词: Vascular Endothelial Growth Factor;    Overall Survival;    NSCLC Patient;    Vascular Endothelial Growth Factor Expression;    Vascular Endothelial Growth Factor Gene;   

DOI  :  10.1186/1471-2407-10-431

 received in 2010-04-05, accepted in 2010-08-16,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundVascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving in carcinogenesis, including lung cancer. We hypothesized that VEGF polymorphisms may affect survival outcomes among locally advanced non-small cell lung cancer (LA-NSCLC) patients.MethodsWe genotyped three potentially functional VEGF variants [-460 T > C (rs833061), -634 G > C (rs2010963), and +936 C > T (rs3025039)] and estimated haplotypes in 124 Caucasian patients with LA-NSCLC treated with definitive radiotherapy. We used Kaplan-Meier log-rank tests, and Cox proportional hazard models to evaluate the association between VEGF variants and overall survival (OS).ResultsGender, Karnofsky's performance scores (KPS) and clinical stage seemed to influence the OS. The variant C genotypes were independently associated with significantly improved OS (CT+CC vs. TT: adjusted hazard ratio [HR] = 0.58; 95% confidence interval [CI] = 0.37-0.92, P = 0.022), compared with the VEGF -460 TT genotype.ConclusionsOur study suggests that VEGF -460 C genotypes may be associated with a better survival of LA-NSCLC patients after chemoradiotherapy. Large studies are needed to confirm our findings.

【 授权许可】

Unknown   
© Guan et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.