Reproductive and obstetric outcomes in mosaic Turner’s Syndrome: a cross-sectional study and review of the literature

Reproductive Biology and Endocrinology

Research

Esen Ulak¹  Özkan Özdamar²  Yasin Ceylan³  Emek Doğer³  Yiğit Çakıroğlu³  Eray Çalışkan³ 

[1] Department of Medical Genetics, Kocaeli University School of Medicine, Kocaeli, Turkey;Department of Obstetrics & Gynecology, Golcuk Military Hospital, Kocaeli, Turkey;Department of Obstetrics & Gynecology, Kocaeli University School of Medicine, Kocaeli, Turkey;

关键词: Mosaicisim;    Turner’s syndrome;    Obstetric outcome;    Reproductive outcome;   

DOI  :  10.1186/s12958-015-0055-7

 received in 2015-03-12, accepted in 2015-05-28,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundTurner’s syndrome (TS) is depicted as a total or partial absence of one X chromosome that results in ovarian dysgenesis. Chances of spontaneous pregnancy in TS are rare and the outcome of the pregnancies is known to be poor with an increased risk of miscarriage and stillbirths. Our aim is to evaluate reproductive and obstetric outcomes of natural conception and in-vitro fertilization (IVF) cycles in mosaic TS patients.MethodsA total of 22 mosaic TS cases (seventeen 45,X/46,XX and five 45,X/46,XX/47,XXX karyotypes) were evaluated.ResultsLive birth and abortion rates were found as 32.7 % and 67.3 %, respectively in 52 pregnancies. Implantation, clinical pregnancy and take home baby rates were detected as 3.7 %, 8.6 % and 5.7 %, respectively per IVF cycle as a result of 35 cycles. Fecundability analysis revealed that 5 % of the cases experienced first pregnancy within 6 months and 8 % within the first 2 years. Mosaicism ratio did not have an effect on the time to the first pregnancy (p = .149).ConclusionOnly a small proportion of the mosaic TS patients conceive in the first 2 years of the marriage. Age of menarche and age of marriage appear not to have any impact on the chance of conceiving. Mosaic TS cases should counseled about the low odds of pregnancy and high miscarriage rates.

【 授权许可】

CC BY   
© Doğer et al. 2015