The role of salt abuse on risk for hypercalciuria

Nutrition Journal

Research

Carlos R Padovani¹  João L Amaro²  José Goldberg²  Patrícia CG Damasio³  Carmen RPR Amaro⁴  Natália B Cunha⁵  Ana C Pichutte⁵ 

[1] Department of Biostatistics, PhD, Biosciences Institute, UNESP, Botucatu, Brazil;Department of Urology, PhD, Faculty at the Botucatu School of Medicine, UNESP, Botucatu, Brazil;Graduate Student, Lithotripsy Service, Botucatu School of Medicine, UNESP, Botucatu, Brazil;Lithotripsy Service, PhD, Faculty at the Botucatu School of Medicine, UNESP, Botucatu, Brazil;Undergraduate Student, School of Nutrition, UNESP, Botucatu, Brazil;

关键词: Sodium Intake;    Salt Intake;    Urinary Stone;    Urinary Calcium Excretion;    Stone Recurrence;   

DOI  :  10.1186/1475-2891-10-3

 received in 2010-06-09, accepted in 2011-01-06,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundElevated sodium excretion in urine resulting from excessive sodium intake can lead to hypercalciuria and contribute to the formation of urinary stones. The aim of this study was to evaluate salt intake in patients with urinary lithiasis and idiopathic hypercalciuria (IH).MethodsBetween August 2007 and June 2008, 105 lithiasic patients were distributed into 2 groups: Group 1 (n = 55): patients with IH (urinary calcium excretion > 250 mg in women and 300 mg in men with normal serum calcium); Group 2 (n = 50): normocalciuric patients (NC). Inclusion criteria were: age over 18 years, normal renal function (creatinine clearance ≥ 60 ml/min), absent proteinuria and negative urinary culture. Pregnant women, patients with intestinal pathologies, chronic diarrhea or using corticoids were excluded. The protocol of metabolic investigation was based on non-consecutive collection of two 24-hour samples for dosages of: calcium, sodium, uric acid, citrate, oxalate, magnesium and urinary volume. Food intake was evaluated by the three-day dietary record quantitative method, and the Body Mass Index (BMI) was calculated and classified according to the World Health Organization (WHO). Sodium intake was evaluated based on 24-hour urinary sodium excretion.ResultsThe distribution in both groups as regards mean age (42.11 ± 10.61 vs. 46.14 ± 11.52), weight (77.14 ± 16.03 vs. 75.99 ± 15.80), height (1.64 ± 0.10 vs. 1.64 ± plusorminus 0.08) and BMI (28.78 ± 5.81 vs. 28.07 ± 5.27) was homogeneous. Urinary excretion of calcium (433.33 ± 141.92 vs. 188.93 ± 53.09), sodium (280.08 ± 100.94 vs. 200.44.93 ± 65.81), uric acid (880.63 ± 281.50 vs. 646.74 ± 182.76) and magnesium (88.78 ± 37.53 vs. 64.34 ± 31.84) was significantly higher in the IH group (p < 0.05). There was no statistical difference in calcium intake between the groups, and there was significantly higher salt intake in patients with IH than in NC.ConclusionsThis study showed that salt intake was higher in patients with IH as compared to NC.

【 授权许可】

CC BY   
© Damasio et al; licensee BioMed Central Ltd. 2011