Birth cohort effect on latent tuberculosis infection prevalence, United States

BMC Infectious Diseases

Research Article

Thomas R Navin¹  Carla A Winston¹ 

[1] Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop E-10, 30333, Atlanta, Georgia, USA;

关键词: Birth Cohort;    Tuberculin Skin Testing;    Purify Protein Derivative;    Interferon Gamma Release Assay;    Prevalence Difference;   

DOI  :  10.1186/1471-2334-10-206

 received in 2010-02-01, accepted in 2010-07-13,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundLatent tuberculosis infection (LTBI) prevalence in the United States decreased approximately 60% in the three decades between the 1971-1972 and 1999-2000 National Health and Nutrition Examination Survey (NHANES) surveys. We examined the effects of birth cohort on LTBI prevalence over time.MethodsUsing weighted data analysis software to account for NHANES survey design, we calculated the difference in LTBI prevalence between 1971-1972 and 1999-2000 for birth cohorts corresponding to 5-year intervals (1912-1916, 1917-1921,1922-1926, 1927-1931, 1932-1936, 1937-1941, 1942-1946).ResultsLTBI prevalence was significantly lower in 1999-2000 compared to 1971-1972 for cohorts born in 1926 or earlier (19% versus 5%), but not for cohorts born 1927-1946 (9% versus 7%). Adjustment for cohort restriction and foreign-birth did not qualitatively change the results.ConclusionsAlthough older age groups have higher rates of TB infection than younger groups, nationally representative U.S. survey data suggest that observed LTBI prevalence in older people represents an underestimate of infection, because of the birth cohort effect and waning immunologic reactivity.

【 授权许可】

CC BY   
© Winston and Navin; licensee BioMed Central Ltd. 2010