Circadian CLOCK gene polymorphisms in relation to sleep patterns and obesity in African Americans: findings from the Jackson heart study

BMC Genetics

Research Article

Adolfo Correa¹  Mario Sims²  Nancy Min²  Samson Y Gebreab³  Rumana J Khan³  Pia Riestra³  Sharon K Davis³  Amadou Gaye³  Ruihua Xu³ 

[1] Jackson Heart Study, Jackson Medical Mall, 350 West Woodrow Wilson Av., Suite 701, 39217, Jackson, MS, USA;Jackson Heart Study, University of Mississippi Medical Center, 350 W Woodrow Wilson Ave, Ste 701, 39213, Jackson, MS, USA;National Human Genome Research Institute Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch Social Epidemiology Research Unit, National Institutes of Health, 10 Center Drive, 20892, Bethesda, MD, USA;

关键词: Single nucleotide polymorphism;    Obesity;    African Americans;    CLOCK gene sleep;    Body mass index;    Adipocytokines;   

DOI  :  10.1186/s12863-017-0522-6

 received in 2016-10-26, accepted in 2017-06-12,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundCircadian rhythms regulate key biological processes and the dysregulation of the intrinsic clock mechanism affects sleep patterns and obesity onset. The CLOCK (circadian locomotor output cycles protein kaput) gene encodes a core transcription factor of the molecular circadian clock influencing diverse metabolic pathways, including glucose and lipid homeostasis. The primary objective of this study was to evaluate the associations between CLOCK single nucleotide polymorphisms (SNPs) and body mass index (BMI). We also evaluated the association of SNPs with BMI related factors such as sleep duration and quality, adiponectin and leptin, in 2962 participants (1116 men and 1810 women) from the Jackson Heart Study. Genotype data for the selected 23 CLOCK gene SNPS was obtained by imputation with IMPUTE2 software and reference phase data from the 1000 genome project. Genetic analyses were conducted with PLINKResultsWe found a significant association between the CLOCK SNP rs2070062 and sleep duration, participants carriers of the T allele showed significantly shorter sleep duration compared to non-carriers after the adjustment for individual proportions of European ancestry (PEA), socio economic status (SES), body mass index (BMI), alcohol consumption and smoking status that reach the significance threshold after multiple testing correction. In addition, we found nominal associations of the CLOCK SNP rs6853192 with longer sleep duration and the rs6820823, rs3792603 and rs11726609 with BMI. However, these associations did not reach the significance threshold after correction for multiple testing.ConclusionsIn this work, CLOCK gene variants were associated with sleep duration and BMI suggesting that the effects of these polymorphisms on circadian rhythmicity may affect sleep duration and body weight regulation in Africans Americans.

【 授权许可】

CC BY   
© The Author(s). 2017