Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials

Lipids in Health and Disease

Review

Yang Yang¹  Hao Wang¹  Dao-Quan Peng¹  Ning Xia² 

[1] Department of Cardiology, the Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, People’s Republic of China;Department of Pulmonary, Xiangya Hospital, Central South University, 410011, Changsha, Hunan, People’s Republic of China;

关键词: Vitamin D;    lipids;    cardiovascular disease;    meta-analysis;   

DOI  :  10.1186/1476-511X-11-42

 received in 2012-02-04, accepted in 2012-03-20,  发布年份 2012

来源: Springer

【 摘 要 】

Observational studies have shown that low serum levels of vitamin D have been associated with an atherogenic lipid profile. However, the intervention studies gave divergent results. We conducted a meta-analysis of randomized controlled trials that evaluated the effects of vitamin D supplementation on blood lipids. A systematic literature search was conducted via MEDLINE, Cochrane library, and EMBASE for randomized controlled clinical trials assessing the effects of vitamin D supplementation on lipids. The mean change in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) from baseline was treated as a continuous variable. In all, 12 clinical trials consisting of 1346 participants were included in the analysis. The pooled estimate of effect for vitamin D supplementation on LDL-C was 3.23 mg/dl (95% confidence interval, 0.55 to 5.90 mg/dl). No statistically significant effects for vitamin D supplementation were observed for TC, HDL-C and TG (differences in means were 1.52 mg/dl (-1.42 to 4.46 mg/dl), -0.14 mg/dl (-0.99 to 0.71 mg/dl) and -1.92 mg/dl (-7.72 to 3.88 mg/dl) respectively). The lipid modulating effects of vitamin D supplementation should be further investigated though large-scale, randomized trials with adequate doses which can effectively elevated the active form of vitamin D in plasma and with proper population which has hyperlipemia as an inclusion criterion.

【 授权许可】

Unknown   
© Wang et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.