Insight into microRNAs’ involvement in hematopoiesis: current standing point of findings

Stem Cell Research & Therapy

Review

Seyed Mahdi Nassiri¹  Neda Ahmadi Afshar¹  Parsa Almasi¹ 

[1] Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Qarib St., Azadi Ave, Tehran, Iran;

关键词: Differentiation;    Myelopoiesis;    Hematopoiesis;    miRNA;   

DOI  :  10.1186/s13287-023-03504-3

 received in 2022-12-28, accepted in 2023-09-20,  发布年份 2023

来源: Springer

【 摘 要 】

Hematopoiesis is a complex process in which hematopoietic stem cells are differentiated into all mature blood cells (red blood cells, white blood cells, and platelets). Different microRNAs (miRNAs) involve in several steps of this process. Indeed, miRNAs are small single-stranded non-coding RNA molecules, which control gene expression by translational inhibition and mRNA destabilization. Previous studies have revealed that increased or decreased expression of some of these miRNAs by targeting several proto-oncogenes could inhibit or stimulate the myeloid and erythroid lineage commitment, proliferation, and differentiation. During the last decades, the development of molecular and bioinformatics techniques has led to a comprehensive understanding of the role of various miRNAs in hematopoiesis. The critical roles of miRNAs in cell processes such as the cell cycle, apoptosis, and differentiation have been confirmed as well. However, the main contribution of some miRNAs is still unclear. Therefore, it seems undeniable that future studies are required to focus on miRNA activities during various hematopoietic stages and hematological malignancy.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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