Exposure to phthalates and bisphenol A are associated with atopic dermatitis symptoms in children: a time-series analysis

Environmental Health

Research

Jihyun Kim¹  Kangmo Ahn¹  Hae-Kwan Cheong²  Eun-Hye Kim²  Byoung-Hak Jeon²  Young-Min Kim³  Youngshin Han³ 

[1] Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 06351, Seoul, Republic of Korea;Environmental Health Center for Atopic Diseases, Samsung Medical Center, 06351, Seoul, Republic of Korea;Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, 2066 Seobu-ro, Jangan-gu, 16419, Suwon, Gyeonggi-do, Republic of Korea;Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 06351, Seoul, Republic of Korea;Environmental Health Center for Atopic Diseases, Samsung Medical Center, 06351, Seoul, Republic of Korea;

关键词: Endocrine disrupting compounds;    Atopic dermatitis;    Phthalate;    Bisphenol A;    Panel study;   

DOI  :  10.1186/s12940-017-0225-5

 received in 2016-11-27, accepted in 2017-02-28,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundDespite increasing evidence on the relationship between exposure to phthalates and bisphenol A with allergies and asthma, reports on atopic dermatitis (AD) with these chemicals are few. We assessed the association between AD symptoms and the exposure to phthalates and bisphenol A and in children. MethodsWe surveyed 18 boys with AD (age 3–7 years) in a day care center in Seoul between May 2009 and April 2010. AD symptoms were recorded by using a daily symptom diary. We collected 460 series of pooled urine twice a day, in the morning and afternoon, over 230 working days and measured the concentrations of mono–2–ethyl-5-oxohexyl phthalate (5-oxo-MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate (5-OH-MEHP), mono-isobutyl phthalate (MnBP) and bisphenol A glucuronide (BPAG) in the pooled urine. Logistic regression was used for statistical analysis.ResultsMost phthalate metabolite levels were higher in the morning than in the afternoon (p < 0.0001). There was seasonal variation in the levels of phthalates and bisphenol A metabolites. Levels of 5-OH-MEHP, MnBP, and BPAG were highest in summer (p < 0.0001). Manifestation of AD symptoms was associated with an increase in urinary levels of MnBP (adjusted odds ratio, aOR = 2.85, 95% CI: 1.12-7.26 per 1 μg/L of MnBP) and BPAG (aOR = 1.79, 95% CI: 0.91-3.52 per 1 μg/L BPAG) on the same day. The levels of MnBP and BPAG in the previous day increased AD symptoms (aOR = 2.74, 95% CI: 1.21-6.20, for 1 μg/L of MnBP and aOR = 2.01, 95% CI: 1.08-3.74 for 1 μg/L BPAG).ConclusionOur results suggest that exposure to phthalates and bisphenol A is associated with aggravation of AD symptoms in children.

【 授权许可】

CC BY   
© The Author(s). 2017