Relationship between epicardial adipose tissue, coronary artery disease and adiponectin in a Mexican population

Cardiovascular Ultrasound

Research

Jorge E Torres-Lopez¹  Jorge L Ble-Castillo¹  Gabriela Borrayo-Sanchez²  Teresa G Yañez-Rivera³  Manuel E Torres-Hernandez⁴  Manuel A Baños-Gonzalez⁵ 

[1] Centro de Investigación y Posgrado, DACS, Universidad Juárez Autónoma de Tabasco (UJAT), Villahermosa, Tabasco, Mexico;Coordinación de Investigación, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico;Departamento de Cardiología, Hospital General de Zona 46, Instituto Mexicano del Seguro Social (IMSS), Villahermosa, Tabasco, Mexico;Departamento de Cardiología, Hospital Regional de Alta Especialidad “Dr. Juan Graham Casasús”, Villahermosa, Tabasco, Mexico;Departamento de Cardiología, Hospital Regional de Alta Especialidad “Dr. Juan Graham Casasús”, Villahermosa, Tabasco, Mexico;Centro de Investigación y Posgrado, DACS, Universidad Juárez Autónoma de Tabasco (UJAT), Villahermosa, Tabasco, Mexico;

关键词: Epicardial adipose tissue;    Coronary artery disease;    Echocardiography;    Adiponectin;   

DOI  :  10.1186/1476-7120-12-35

 received in 2014-06-12, accepted in 2014-08-26,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe amount of epicardial adipose tissue (EAT) around the heart has been identified as an independent predictor of coronary artery disease (CAD), potentially through local release of inflammatory cytokines. Ethnic differences have been observed, but no studies have investigated this relationship in the Mexican population. The objective of the present study was to evaluate whether a relationship exist between EAT thickness assessed via echocardiography with CAD and adiponectin levels in a Mexican population.MethodsWe studied 153 consecutive patients who underwent coronary angiography and transthoracic echocardiography (TTE). EAT thickness on the free wall of the right ventricle was measured at the end of systole from parasternal long and short axis views of three consecutive cardiac cycles. Coronary angiograms were analyzed for the presence, extent and severity of CAD. Serum adiponectin, lipids, glucose, C-reactive protein and fibrinogen were determined.ResultsEAT thickness was greater in patients with CAD than in those without CAD from both parasternal long (5.39 ± 1.75 mm vs 4.00 ± 1.67 mm p < 0.0001) and short-axis views (5.23 ± 1.67 vs 4.12 ± 1.77, p = 0.001). EAT thickness measured from parasternal long and short-axis showed a statistically significant positive correlation with age (r = 0.354, p < 0.001; r = 0.286, p < 0.001 respectively), and waist circumference (r = 0.189, p = 0.019; r = 0.217, p = 0.007 respectively). A significant negative correlation between EAT thickness from the parasternal long axis with cholesterol-HDL was observed (r = -0.163, p = 0.045). No significant correlation was found between epicardial fat thickness and serum adiponectin or with the severity of CAD.ConclusionsEAT thickness was greater in patients with CAD. However, no correlation was observed with the severity of the disease or with serum adiponectin levels. EAT thickness measured by echocardiography might provide additional information for risk assessment and prediction of CAD.

【 授权许可】

Unknown   
© Yañez-Rivera et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.