The Quartet Data Portal: integration of community-wide resources for multiomics quality control

Genome Biology

Software

Weida Tong¹  Huixiao Hong¹  Andreas Scherer²  Shengpeng Yang³  Wenming Xiao⁴  Jun Shang⁵  Qiaochu Chen⁵  Yueqiang Song⁵  Yaqing Liu⁵  Yuanting Zheng⁵  Qingwang Chen⁵  Zhihui Li⁵  Luyao Ren⁵  Ying Yu⁵  Naixin Zhang⁵  Jingcheng Yang⁶  Leming Shi⁷ 

[1] Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA;Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland;EATRIS ERIC-European Infrastructure for Translational Medicine, Amsterdam, the Netherlands;Intelligent Storage, Alibaba Cloud, Alibaba Group, Hangzhou, Zhejiang, China;Office of Oncological Diseases, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA;State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute and Shanghai Cancer Center, Fudan University, Shanghai, China;State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute and Shanghai Cancer Center, Fudan University, Shanghai, China;Greater Bay Area Institute of Precision Medicine, Guangzhou, Guangdong, China;State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute and Shanghai Cancer Center, Fudan University, Shanghai, China;International Human Phenome Institutes (Shanghai), Shanghai, China;

关键词: Quartet Data Portal;    Multiomics;    Quartet Project;    Quality control;    Reference materials;    Reference datasets;    Performance evaluation;    Reproducibility;    Evolving technologies;    Interactive visualization;   

DOI  :  10.1186/s13059-023-03091-9

 received in 2022-11-08, accepted in 2023-10-17,  发布年份 2023

来源: Springer

【 摘 要 】

The Quartet Data Portal facilitates community access to well-characterized reference materials, reference datasets, and related resources established based on a family of four individuals with identical twins from the Quartet Project. Users can request DNA, RNA, protein, and metabolite reference materials, as well as datasets generated across omics, platforms, labs, protocols, and batches. Reproducible analysis tools allow for objective performance assessment of user-submitted data, while interactive visualization tools support rapid exploration of reference datasets. A closed-loop “distribution-collection-evaluation-integration” workflow enables updates and integration of community-contributed multiomics data. Ultimately, this portal helps promote the advancement of reference datasets and multiomics quality control.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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