Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease

Journal of Cardiovascular Magnetic Resonance

Research

Raymond Y Kwong¹  Chu-Pak Lau²  Carmen Wing-Sze Chan²  Hung-Fat Tse³  Yok-Lam Kwong⁴ 

[1] Cardiac Magnetic Resonance Imaging, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, USA;Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong;Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong;Haematology Division, Department of Medicine, the University of Hong Kong, Queen Mary Hospital, Hong Kong;Haematology Division, Department of Medicine, the University of Hong Kong, Queen Mary Hospital, Hong Kong;

关键词: Cardiovascular Magnetic Resonance;    Bone Marrow Cell;    Late Gadolinium Enhancement;    Myocardial Blood Flow;    Severe Coronary Artery Disease;   

DOI  :  10.1186/1532-429X-12-6

 received in 2009-01-07, accepted in 2010-01-25,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundRecent studies suggested that bone marrow (BM) cell implantation in patients with severe chronic coronary artery disease (CAD) resulted in modest improvement in symptoms and cardiac function. This study sought to investigate the functional changes that occur within the chronic human ischaemic myocardium after direct endomyocardial BM cells implantation by cardiovascular magnetic resonance (CMR).Methods and ResultsWe compared the interval changes of left ventricular ejection fraction (LVEF), myocardial perfusion reserve and the extent of myocardial scar by using late gadolinium enhancement CMR in 12 patients with severe CAD. CMR was performed at baseline and at 6 months after catheter-based direct endomyocardial autologous BM cell (n = 12) injection to viable ischaemic myocardium as guided by electromechanical mapping. In patients randomized to receive BM cell injection, there was significant decrease in percentage area of peri-infarct regions (-23.6%, P = 0.04) and increase in global LVEF (+9.0%, P = 0.02), the percentage of regional wall thickening (+13.1%, P= 0.04) and MPR (+0.25%, P = 0.03) over the target area at 6-months compared with baseline.ConclusionsDirect endomyocardial implantation of autologous BM cells significantly improved global LVEF, regional wall thickening and myocardial perfusion reserve, and reduced percentage area of peri-infarct regions in patients with severe CAD.

【 授权许可】

Unknown   
© Chan et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.