Differential effects of dietary protein sources on postprandial low-grade inflammation after a single high fat meal in obese non-diabetic subjects

Nutrition Journal

Research

Jens Holmer-Jensen¹  Kjeld Hermansen¹  Steen B Pedersen¹  Lene S Mortensen¹  Karl-Heinz Herzig²  Toni Karhu² 

[1]Department of Endocrinology and Metabolism MEA, Aarhus University Hospital, Aarhus, Denmark

[2]Institute of Biomedicine and Biocenter of Oulu Faculty of Medicine, Finland

关键词: obesity;    metabolic syndrome;    dietary protein;    nutrition;    inflammation;    cytokines;    postprandial period;   

DOI  :  10.1186/1475-2891-10-115

 received in 2011-06-27, accepted in 2011-10-19,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundObesity is a state of chronic low-grade inflammation. Chronic low-grade inflammation is associated with the pathophysiology of both type-2 diabetes and atherosclerosis. Prevention or reduction of chronic low-grade inflammation may be advantageous in relation to obesity related co-morbidity. In this study we investigated the acute effect of dietary protein sources on postprandial low-grade inflammatory markers after a high-fat meal in obese non-diabetic subjects.MethodsWe conducted a randomized, acute clinical intervention study in a crossover design. We supplemented a fat rich mixed meal with one of four dietary proteins - cod protein, whey isolate, gluten or casein. 11 obese non-diabetic subjects (age: 40-68, BMI: 30.3-42.0 kg/m2) participated and blood samples were drawn in the 4 h postprandial period. Adiponectin was estimated by ELISA methods and cytokines were analyzed by multiplex assay.ResultsMCP-1 and CCL5/RANTES displayed significant postprandial dynamics. CCL5/RANTES initially increased after all meals, but overall CCL5/RANTES incremental area under the curve (iAUC) was significantly lower after the whey meal compared with the cod and casein meals (P = 0.0053). MCP-1 was initially suppressed after all protein meals. However, the iAUC was significantly higher after whey meal compared to the cod and gluten meals (P = 0.04).ConclusionWe have demonstrated acute differential effects on postprandial low grade inflammation of four dietary proteins in obese non-diabetic subjects. CCL5/RANTES initially increased after all meals but the smallest overall postprandial increase was observed after the whey meal. MCP-1 was initially suppressed after all 4 protein meals and the whey meal caused the smallest overall postprandial suppression.Trial RegistrationClinicalTrials.gov ID: NCT00863564

【 授权许可】

CC BY   
© Holmer-Jensen et al; licensee BioMed Central Ltd. 2011