Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis

BMC Infectious Diseases

Research Article

Joris FA Meys¹  Philippe De Sutter²  Hans Verstraelen³  Davy Vanden Broeck⁴  Carolyne Bosire⁴  Marleen Temmerman⁴  Evy Gillet⁵ 

[1] Department of Applied mathematics, biometrics and process control, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium;Department of Gynaecology, Vrije Universiteit Brussel, Brussels, Belgium;Department of Obstetrics and Gynaecology, Ghent University Hospital, Ghent, Belgium;International Centre for Reproductive Health (ICRH), Ghent University, Ghent, Belgium;International Centre for Reproductive Health (ICRH), Ghent University, Ghent, Belgium;Department of Gynaecology, Vrije Universiteit Brussel, Brussels, Belgium;

关键词: Bacterial Vaginosis;    Secretory Leukocyte Protease Inhibitor;    Report Odds Ratio;    Vaginal Fluid;    Gardnerella Vaginalis;   

DOI  :  10.1186/1471-2334-11-10

 received in 2010-05-07, accepted in 2011-01-11,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundBacterial vaginosis (BV), an alteration of vaginal flora involving a decrease in Lactobacilli and predominance of anaerobic bacteria, is among the most common cause of vaginal complaints for women of childbearing age. It is well known that BV has an influence in acquisition of certain genital infections. However, association between BV and cervical human papillomavirus (HPV) infection has been inconsistent among studies. The objective of this meta-analysis of published studies is to clarify and summarize published literature on the extent to which BV is associated with cervical HPV infection.MethodsMedline and Web of Science were systematically searched for eligible publications until December 2009. Articles were selected based on inclusion and exclusion criteria. After testing heterogeneity of studies, meta-analysis was performed using random effect model.ResultsTwelve eligible studies were selected to review the association between BV and HPV, including a total of 6,372 women. The pooled prevalence of BV was 32%. The overall estimated odds ratio (OR) showed a positive association between BV and cervical HPV infection (OR, 1.43; 95% confidence interval, 1.11-1.84).ConclusionThis meta-analysis of available literature resulted in a positive association between BV and uterine cervical HPV infection.

【 授权许可】

Unknown   
© Gillet et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.