Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis

Molecular Cancer

Review

Erin A. Marshall¹  Daiana D. Becker-Santos¹  Elizabeth C. Halvorsen¹  David A. Rowbotham¹  Katey S. S. Enfield¹  Jennifer Y. Kennett¹  Stephen Lam¹  Kevin W. Ng¹  Sonia H. Y. Kung²  William W. Lockwood³  Emily A. Vucic³  Victor D. Martinez³  Kevin L. Bennewith³  Emma M. Conway³  Wan L. Lam⁴  John C. English⁵  Ninan Abraham⁶  Adam W. Plumb⁷ 

[1] Department of Integrative Oncology, British Columbia Cancer Agency, Vancouver, Canada;Department of Integrative Oncology, British Columbia Cancer Agency, Vancouver, Canada;British Columbia Cancer Research Centre, Vancouver, Canada;Department of Integrative Oncology, British Columbia Cancer Agency, Vancouver, Canada;Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada;Department of Integrative Oncology, British Columbia Cancer Agency, Vancouver, Canada;Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada;British Columbia Cancer Research Centre, Vancouver, Canada;Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada;Departments of Microbiology and Immunology, University of British Columbia, Vancouver, Canada;Departments of Microbiology and Immunology, University of British Columbia, Vancouver, Canada;Department of Zoology, University of British Columbia, Vancouver, Canada;

关键词: Th17;    IL-17;    Regulatory T cell;    Treg;    Lung cancer;    Inflammation;    Cancer immunology;    Tumor microenvironment;    Tumorigenesis;    Prognosis;   

DOI  :  10.1186/s12943-016-0551-1

 received in 2016-07-14, accepted in 2016-10-18,  发布年份 2016

来源: Springer

【 摘 要 】

Lung cancer is a leading cause of cancer-related deaths worldwide. Lung cancer risk factors, including smoking and exposure to environmental carcinogens, have been linked to chronic inflammation. An integral feature of inflammation is the activation, expansion and infiltration of diverse immune cell types, including CD4+ T cells. Within this T cell subset are immunosuppressive regulatory T (Treg) cells and pro-inflammatory T helper 17 (Th17) cells that act in a fine balance to regulate appropriate adaptive immune responses.In the context of lung cancer, evidence suggests that Tregs promote metastasis and metastatic tumor foci development. Additionally, Th17 cells have been shown to be an integral component of the inflammatory milieu in the tumor microenvironment, and potentially involved in promoting distinct lung tumor phenotypes. Studies have shown that the composition of Tregs and Th17 cells are altered in the tumor microenvironment, and that these two CD4+ T cell subsets play active roles in promoting lung cancer progression and metastasis.We review current knowledge on the influence of Treg and Th17 cells on lung cancer tumorigenesis, progression, metastasis and prognosis. Furthermore, we discuss the potential biological and clinical implications of the balance among Treg/Th17 cells in the context of the lung tumor microenvironment and highlight the potential prognostic function and relationship to metastasis in lung cancer.

【 授权许可】

CC BY   
© The Author(s). 2016