Functional imaging with diffusion-weighted MRI for lung biopsy planning: initial experience

World Journal of Surgical Oncology

Technical Innovations

Bruno C Odisio¹  Myrna C B Godoy¹  Rubens Chojniak²  Almir G V Bitencourt²  Marcos D Guimaraes²  Charles E Zurstrassen³  Chiang C Tyng³  Bruno Hochhegger⁴  Edson Marchiori⁵  Jefferson L Gross⁶ 

[1] Department of Diagnostic Radiology, MD Anderson Cancer Center, 1515 Holcombe Blvd, Zip 77030, Houston, TX, USA;Department of Imaging, AC Camargo Cancer Center, Rua Paulo Orozimbo, 726, Aclimação, Zip 01535-001, São Paulo, SP, Brazil;Department of Interventional Radiology, AC Camargo Cancer Center, Rua Paulo Orozimbo, 726, Aclimação, Zip 01535-001, São Paulo, SP, Brazil;Department of Radiology, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Prof. Annes Dias, 295, Centro, Zip 90020-090, Porto Alegre, RS, Brazil;Department of Radiology, Universidade Federal do Rio de Janeiro, Rua Thomaz Cameron, 438,Valparaiso, Zip 25685-120, Petrópolis, RJ, Brazil;Department of Thoracic Surgery, AC Camargo Cancer Center, Rua Paulo Orozimbo, 726, Aclimação, Zip 01535-001, São Paulo, SP, Brazil;

关键词: Functional imaging;    MRI-guided biopsy;    DWI;    Transthoracic biopsy;    Lung lesion;    PET/CT-guided biopsy;   

DOI  :  10.1186/1477-7819-12-203

 received in 2013-12-23, accepted in 2014-06-29,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe purpose of this study was to evaluate the usefulness of diffusion-weighted magnetic resonance imaging (DW-MRI) and positron emission tomography/computed tomography (PET/CT) in planning transthoracic CT-guided biopsies of lung lesions.MethodsThirteen patients with lung lesions suspicious for malignancy underwent CT-guided biopsy. Chest DW-MRI and apparent diffusion coefficient (ADC) calculation were performed to aid biopsy planning with fused images. MRI was indicated due to large heterogeneous masses, association with lung atelectasis/consolidation/necrosis, and/or divergent results of other biopsy type and histopathology versus clinical/radiological suspicion. Eight patients underwent PET/CT to identify appropriate areas for biopsy.ResultsMean patient (n = 9 males) age was 59 (range, 30 to 78) years. Based on DW-MRI results, biopsies targeted the most suspicious areas within lesions. All biopsied areas showed higher DW signal intensity and lower ADCs (mean, 0.79 (range, 0.54 to 1.2) × 10−3 mm2/s), suggesting high cellularity. In patients who underwent PET/CT, areas with higher 18-fluorodeoxyglucose concentrations (standard uptake value mean, 7.7 (range, 3.6 to 13.7)) corresponded to areas of higher DW signal intensity and lower ADCs. All biopsies yielded adequate material for histopathological diagnosis.ConclusionsFunctional imaging is useful for lung biopsy planning. DW-MRI and PET/CT increase overall performance and enable the collection of adequate material for specific diagnosis.

【 授权许可】

CC BY   
© Guimaraes et al.; licensee BioMed Central Ltd. 2014