期刊论文详细信息
BMC Geriatrics
Association between pain, neuropsychiatric symptoms, and physical function in dementia: a systematic review and meta-analysis
Research Article
Bettina S Husebo1  Wilco P Achterberg2  Margot WM de Waal2  Annelore H van Dalen-Kok2  Marjoleine JC Pieper3  Albert Lukas4 
[1] Department of Public Health and Primary Care, Centre for Elderly and Nursing Home Medicine, University of Bergen, Bergen, Norway;Stavanger University Hospital, Bergen, Norway;Department of Public Health and Primary Care, Leiden University Medical Centre, PO Box 9600, Hippocratespad 21 Post zone V0-P, 2300, Leiden, RC, The Netherlands;Department of Public Health and Primary Care, Leiden University Medical Centre, PO Box 9600, Hippocratespad 21 Post zone V0-P, 2300, Leiden, RC, The Netherlands;Department of General Practice & Elderly Care Medicine, VU University Medical Centre Amsterdam, van der Boechorststraat 7, 1081, Amsterdam, BT, The Netherlands;Malteser Hospital Bonn/Rhein-Sieg, Centre of Geriatric Medicine, Academic Hospital University of Bonn, Von-Hompesch-Straße 1, 53123, Bonn, Germany;
关键词: Pain;    Dementia;    Neuropsychiatric symptoms;    Physical function;    Associations;   
DOI  :  10.1186/s12877-015-0048-6
 received in 2014-11-20, accepted in 2015-04-01,  发布年份 2015
来源: Springer
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【 摘 要 】

BackgroundPain, neuropsychiatric symptoms (NPS) and functional impairment are prevalent in patients with dementia and pain is hypothesized to be causal in both neuropsychiatric symptoms (NPS) and functional impairment. As the exact nature of the associations is unknown, this review examines the strength of associations between pain and NPS, and pain and physical function in patients with dementia. Special attention is paid to the description of measurement instruments and the methods used to detect pain, NPS and physical function.MethodsA systematic search was made in the databases of PubMed (Medline), Embase, Cochrane, Cinahl, PsychINFO, and Web of Science. Studies were included that described associations between pain and NPS and/or physical function in patients with moderate to severe dementia.ResultsThe search yielded 22 articles describing 18 studies, including two longitudinal studies. Most evidence was found for the association between pain and depression, followed by the association between pain and agitation/aggression. The longitudinal studies reported no direct effects between pain and NPS but some indirect effects, e.g. pain through depression. Although some association was established between pain and NPS, and pain and physical function, the strength of associations was relatively weak. Interestingly, only three studies used an observer rating scale for pain-related behaviour.ConclusionsAvailable evidence does not support strong associations between pain, NPS and physical function. This might be due to inadequate use or lack of rating scales to detect pain-related behaviour. These results show that the relationship between pain and NPS, as well as with physical function, is complicated and warrants additional longitudinal evaluation.

【 授权许可】

CC BY   
© van Dalen-Kok et al.; licensee BioMed Central. 2015

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