Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand

Malaria Journal

Case Report

Mallika Imwong¹  Pratap Singhasivanon²  Niklas Lindegardh³  Laurent Rénia⁴  Bruce Russell⁴  Georges Snounou⁵  Marcus J Rijken⁶  Machteld E Boel⁶  Mara L Leimanis⁶  Aung Pyae Phyo⁶  Rose McGready⁷  François Nosten⁷  Atis Muehlenbachs⁸ 

[1] Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, 10400, Bangkok, Thailand;Faculty of Tropical Medicine, Mahidol University, 10400, Bangkok, Thailand;Faculty of Tropical Medicine, Mahidol University, 10400, Bangkok, Thailand;Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, CCVTM, OX3 7LJ, Oxford, UK;Laboratory of Malaria Immunobiology, Singapore Immunology Network, Biopolis, Agency for Science Technology and Research (A*STAR), Singapore;Laboratory of Malaria Immunobiology, Singapore Immunology Network, Biopolis, Agency for Science Technology and Research (A*STAR), Singapore;INSERM UMR S-945, F-75013, Paris, France;Université Pierre & Marie Curie, Faculté de Médecine Pitié-Salpêtrière, F-75013, Paris, France;Shoklo Malaria Research Unit, PO Box 46, 63110, Mae Sot, Tak, Thailand;Shoklo Malaria Research Unit, PO Box 46, 63110, Mae Sot, Tak, Thailand;Faculty of Tropical Medicine, Mahidol University, 10400, Bangkok, Thailand;Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, CCVTM, OX3 7LJ, Oxford, UK;University of Washington, 1959 NE Pacific Street, 98195, Seattle, WA, USA;

关键词: Chloroquine;    Artesunate;    Vivax Malaria;    Primaquine;    Amodiaquine;   

DOI  :  10.1186/1475-2875-10-113

 received in 2011-03-03, accepted in 2011-05-05,  发布年份 2011

来源: Springer

【 摘 要 】

Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.

【 授权许可】

CC BY   
© Rijken et al; licensee BioMed Central Ltd. 2011