Curative resection of gallbladder cancer with liver invasion and hepatic metastasis after chemotherapy with gemcitabine plus S-1: report of a case

World Journal of Surgical Oncology

Case Report

Keita Kai¹  Atsushi Miyoshi²  Hiroki Koga²  Hirokazu Noshiro²  Takashi Okumura²  Hiroaki Nakamura²  Kenji Kitahara²  Jun Nakamura²  Takao Ide²  Yasushi Ide³ 

[1] Department of Pathology and Microbiology, Saga University Faculty of Medicine, Nabeshima 5-1-1, 849-8501, Saga, Japan;Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5-1-1, 849-8501, Saga, Japan;Oda Hospital, Ohaza Takatsuhara 4360, 849-1932, Kashima City, Saga, Japan;

关键词: chemotherapy;    gallbladder cancer;    gemcitabine;    liver metastasis;    S-1;   

DOI  :  10.1186/1477-7819-12-326

 received in 2014-04-19, accepted in 2014-10-20,  发布年份 2014

来源: Springer

【 摘 要 】

A 62-year-old woman diagnosed with gallbladder cancer exhibiting broad liver invasion and metastasis to Couinaud’s hepatic segments 4 and 8 (S4 and S8) consulted her regular doctor. Owing to the presence of liver metastases, she received treatment with gemcitabine plus S-1. After four cycles of chemotherapy, the size of the main lesion dramatically decreased and the two liver metastases disappeared. After six cycles of chemotherapy, the patient was referred to our hospital for surgical treatment. Upon admission, there was no evidence of any distant metastasis, based on a detailed radiological examination. Therefore, we performed cholecystectomy and central bisegmentectomy of the liver after obtaining the patient’s informed consent. Pathological examination demonstrated viable cancer cells with granuloma formation and calcification in the gallbladder, as well as regenerative changes without viable cancer cells in S4 and S8 of the liver. Gemcitabine plus S-1 was again administered as postoperative adjuvant chemotherapy. One and a half years after the surgery, there were no signs of recurrence. In patients selected according to their response to chemotherapy, surgical treatment might therefore be effective against gallbladder cancer with metastasis.

【 授权许可】

Unknown   
© Okumura et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.