Extra-gastrointestinal stromal tumor of the pancreas: case report and review of the literature

World Journal of Surgical Oncology

Case Report

Davide Pastorelli¹  Sara Pizzi²  Valentina Beltrame³  Mario Gruppo³  Cosimo Sperti³  Stefano Merigliano³ 

[1] Department of Oncology, Rare Tumors Unit, Veneto Institute of Oncology, Padua, Italy;Department of Pathology, University of Padua, Padua, Italy;Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Giustiniani 2, 35128, Padua, Italy;

关键词: Differential diagnosis;    Gastrointestinal stromal tumor;    Pancreas;    Pancreatectomy;    Pancreatic neoplasms;   

DOI  :  10.1186/1477-7819-12-105

 received in 2013-09-09, accepted in 2014-04-07,  发布年份 2014

来源: Springer

【 摘 要 】

Primary extra-gastrointestinal stromal tumor (EGISTs) arising in the pancreas is extremely rare: only 20 cases have previously been reported in the English literature from 2000 to 2013. We reported a case of EGIST of the pancreas in a 69-year-old woman who presented with abdominal pain and with a solid, heterogeneously enhancing neoplasm in the uncinate process of the pancreas, revealed preoperatively by an abdominal computed tomography scan. A diagnosis of neuroendocrine tumor was suggested. Positron emission tomography with 68Ga-DOTATOC did not show pathological accumulation of the tracer in the pancreas. The patient underwent enucleation, under ultrasonic guidance, of the pancreatic tumor that emerged to the surface of the pancreas. Histopathology and immunohistochemical examination confirmed the final diagnosis of EGIST of the pancreas (CD117+), with one mitosis per 50 high-power fields. Although rarely, GIST can involve the pancreas as a primary site, and this tumor should be considered in the differential diagnosis of pancreatic neoplasms.

【 授权许可】

Unknown   
© Beltrame et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.