Mortality among patients with tuberculosis requiring intensive care: a retrospective cohort study

BMC Infectious Diseases

Research Article

Denise R Silva¹  Marcelo B Gazzana¹  Paulo TR Dalcin¹  Diego M Menegotto¹  Luis F Schulz¹ 

[1] Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS); Hospital de Clínicas de Porto Alegre, RS, Brazil;

关键词: Intensive Care Unit;    Human Immunodeficiency Virus;    Acute Renal Failure;    Acute Respiratory Distress Syndrome;    Intensive Care Unit Admission;   

DOI  :  10.1186/1471-2334-10-54

 received in 2009-07-13, accepted in 2010-03-07,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundTo describe the characteristics of patients with tuberculosis (TB) requiring intensive care and to identify the factors that predicts in-hospital mortality in a city of a developing country with intermediate-to-high TB endemicity.MethodsWe conducted a retrospective, cohort study, between November 2005 and November 2007. The patients with TB requiring intensive care were included. Predictors of mortality were assessed. The primary outcome was the in-hospital mortality.ResultsDuring the study period, 67 patients with TB required intensive care. Of them, 62 (92.5%) had acute respiratory failure and required mechanical ventilation. Forty-four (65.7%) patients died. Coinfection with human immunodeficiency virus was present in 46 (68.7%) patients. Early intensive care unit admission and ventilator-associated pneumonia were independently associated with the in-hospital mortality.ConclusionsIn this study we found a high mortality rate in TB patients requiring intensive care, especially in those with an early ICU admission.

【 授权许可】

CC BY   
© Silva et al; licensee BioMed Central Ltd. 2010